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Abstract：
UNASSIGNED: The purpose of the study was to characterize the differences in the course of Epstein-Barr virus (EBV) primary infection-induced hepatitis between patients treated with steroids due to complications of infectious mononucleosis (IM) and those not receiving such therapy.
UNASSIGNED: We analyzed the changes in the activity of liver enzymes and differences in abdominal ultrasound results. The study was based on reviewing the medical records of children hospitalized for primary EBV infection at the Department of Children\'s Infectious Diseases, Medical University of Warsaw, Regional Hospital of Infectious Diseases in Warsaw, between August 2017 and March 2023. The study population was divided into two groups: patients treated with steroids (Group 1) and children not receiving steroids (Group 2).
UNASSIGNED: Significant differences were obtained for alanine aminotransferase activity only in the first week of IM (205.34 ±115.40 vs. 288.82 ±170.16 IU/l for Group 1 and 2, respectively; p = 0.024), and for aspartate aminotransferase in the first (170.63 ±159.47 vs. 218.85 ±128.22 IU/l for Group 1 and 2, respectively; p = 0.009) and the third week (151.09 ±138.57 vs. 235.50 ±170.27 IU/l for Group 1 and 2, respectively; p = 0.016). The analysis of the results of laboratory tests for the diagnosis of cholestasis (γ-glutamyl transferase and total serum bilirubin concentrations with fractions) did not show significant differences between the groups.
UNASSIGNED: Our results indicated that the two cohorts of patients may differ in the course of hepatitis associated with primary EBV infection, especially at the beginning of the disease, when the laboratory features of hepatitis were less pronounced in children treated with steroids.
UNASSIGNED: We analyzed the changes in the activity of liver enzymes and differences in abdominal ultrasound results. The study was based on reviewing the medical records of children hospitalized for primary EBV infection at the Department of Children\'s Infectious Diseases, Medical University of Warsaw, Regional Hospital of Infectious Diseases in Warsaw, between August 2017 and March 2023. The study population was divided into two groups: patients treated with steroids (Group 1) and children not receiving steroids (Group 2).
UNASSIGNED: Significant differences were obtained for alanine aminotransferase activity only in the first week of IM (205.34 ±115.40 vs. 288.82 ±170.16 IU/l for Group 1 and 2, respectively; p = 0.024), and for aspartate aminotransferase in the first (170.63 ±159.47 vs. 218.85 ±128.22 IU/l for Group 1 and 2, respectively; p = 0.009) and the third week (151.09 ±138.57 vs. 235.50 ±170.27 IU/l for Group 1 and 2, respectively; p = 0.016). The analysis of the results of laboratory tests for the diagnosis of cholestasis (γ-glutamyl transferase and total serum bilirubin concentrations with fractions) did not show significant differences between the groups.
UNASSIGNED: Our results indicated that the two cohorts of patients may differ in the course of hepatitis associated with primary EBV infection, especially at the beginning of the disease, when the laboratory features of hepatitis were less pronounced in children treated with steroids.
摘要：
■该研究的目的是表征因传染性单核细胞增多症（IM）并发症而接受类固醇治疗的患者与未接受此类治疗的患者之间爱泼斯坦-巴尔病毒（EBV）原发性感染诱发的肝炎的病程差异。
■我们分析了肝酶活性的变化以及腹部超声结果的差异。这项研究是基于儿童感染科原发性EBV感染住院儿童的医疗记录，华沙医科大学,华沙地区传染病医院，2017年8月至2023年3月。研究人群分为两组：接受类固醇治疗的患者（第1组）和未接受类固醇治疗的儿童（第2组）。
■仅在IM的第一周获得丙氨酸转氨酶活性的显着差异（205.34±115.40vs.第1组和第2组分别为288.82±170.16IU/l；p=0.024），和天冬氨酸转氨酶在第一（170.63±159.47vs.第1组和第2组分别为218.85±128.22IU/l；p=0.009）和第三周（151.09±138.57vs.第1组和第2组分别为235.50±170.27IU/l；p=0.016)。对诊断胆汁淤积的实验室检查结果（γ-谷氨酰转移酶和血清总胆红素浓度的分数）的分析显示两组之间没有显着差异。
■我们的结果表明，两组患者在与原发性EBV感染相关的肝炎病程中可能存在差异，尤其是在疾病开始时，在接受类固醇治疗的儿童中，肝炎的实验室特征不太明显。
■我们分析了肝酶活性的变化以及腹部超声结果的差异。这项研究是基于儿童感染科原发性EBV感染住院儿童的医疗记录，华沙医科大学,华沙地区传染病医院，2017年8月至2023年3月。研究人群分为两组：接受类固醇治疗的患者（第1组）和未接受类固醇治疗的儿童（第2组）。
■仅在IM的第一周获得丙氨酸转氨酶活性的显着差异（205.34±115.40vs.第1组和第2组分别为288.82±170.16IU/l；p=0.024），和天冬氨酸转氨酶在第一（170.63±159.47vs.第1组和第2组分别为218.85±128.22IU/l；p=0.009）和第三周（151.09±138.57vs.第1组和第2组分别为235.50±170.27IU/l；p=0.016)。对诊断胆汁淤积的实验室检查结果（γ-谷氨酰转移酶和血清总胆红素浓度的分数）的分析显示两组之间没有显着差异。
■我们的结果表明，两组患者在与原发性EBV感染相关的肝炎病程中可能存在差异，尤其是在疾病开始时，在接受类固醇治疗的儿童中，肝炎的实验室特征不太明显。
