PDF(Pubmed)
Abstract：
UNASSIGNED: Zinc is an essential trace element involved in different physiological functions. During pregnancy, it plays a crucial role in healthy embryogenesis. Abortion is the most severe problem associated with early pregnancy complications. This study aims to compare the levels of Zn in mothers with and without abortion.
UNASSIGNED: This study is a systematic review and meta-analysis of studies published between 1980 and 2022 in PubMed, Science Direct, Pro Quest, Wiley, Web of Science, and Scopus databases. The search was conducted using both main and Mesh keywords, specifically targeting terms related to abortion, pregnancy loss, and zinc. Heterogeneity in the studies included in the meta-analysis was evaluated using statistical tests such as the chi-square test, I2, and forest plots. Publication bias was assessed using Begg\'s and Egger\'s tests. All analyses were conducted using Stata 15, and statistical significance was considered at p < 0.05.
UNASSIGNED: In general, nine studies were included in this analysis. Based on the results of the meta-analysis, the mean difference in the Zn level between mothers with and without abortion is equal to 193.18 (95 % CI; 107.11 to 279.25, P ≤ 0.001). In other words, the level of Zn in the group of mothers without abortion is 193 units higher than the group of mothers with abortion. The investigation into the comparison of Zn levels in mothers with and without abortion did not reveal any indication of publication bias according to both Begg\'s test (P-value = 0.858) and Egger\'s test (P-value = 0.270).
UNASSIGNED: the study findings indicate a significant association between lower levels of Zn in mothers with abortion compared to mothers without abortion. This suggests that a higher level of Zn may have a preventive effect on the occurrence of abortion in pregnant women. The data also highlights the positive role of trace metals, particularly Zn, in influencing pregnancy outcomes and suggests that maintaining adequate levels of Zn may reduce the likelihood of abortion occurrence, along with other contributing factors. It is important to note that further research, including prospective cohort and experimental studies, is needed to provide more substantial evidence and strengthen these findings.
UNASSIGNED: This study is a systematic review and meta-analysis of studies published between 1980 and 2022 in PubMed, Science Direct, Pro Quest, Wiley, Web of Science, and Scopus databases. The search was conducted using both main and Mesh keywords, specifically targeting terms related to abortion, pregnancy loss, and zinc. Heterogeneity in the studies included in the meta-analysis was evaluated using statistical tests such as the chi-square test, I2, and forest plots. Publication bias was assessed using Begg\'s and Egger\'s tests. All analyses were conducted using Stata 15, and statistical significance was considered at p < 0.05.
UNASSIGNED: In general, nine studies were included in this analysis. Based on the results of the meta-analysis, the mean difference in the Zn level between mothers with and without abortion is equal to 193.18 (95 % CI; 107.11 to 279.25, P ≤ 0.001). In other words, the level of Zn in the group of mothers without abortion is 193 units higher than the group of mothers with abortion. The investigation into the comparison of Zn levels in mothers with and without abortion did not reveal any indication of publication bias according to both Begg\'s test (P-value = 0.858) and Egger\'s test (P-value = 0.270).
UNASSIGNED: the study findings indicate a significant association between lower levels of Zn in mothers with abortion compared to mothers without abortion. This suggests that a higher level of Zn may have a preventive effect on the occurrence of abortion in pregnant women. The data also highlights the positive role of trace metals, particularly Zn, in influencing pregnancy outcomes and suggests that maintaining adequate levels of Zn may reduce the likelihood of abortion occurrence, along with other contributing factors. It is important to note that further research, including prospective cohort and experimental studies, is needed to provide more substantial evidence and strengthen these findings.
摘要：
■锌是参与不同生理功能的必需微量元素。在怀孕期间,它在健康的胚胎发育中起着至关重要的作用。堕胎是与早期妊娠并发症相关的最严重的问题。这项研究旨在比较有流产和没有流产的母亲的锌水平。
■本研究是对1980年至2022年在PubMed上发表的研究的系统回顾和荟萃分析，科学直接，专业任务,威利,WebofScience,和Scopus数据库。搜索使用main和Mesh关键字进行，专门针对与堕胎有关的术语，怀孕失败,和锌。使用卡方检验等统计检验评估荟萃分析中包含的研究中的异质性，I2和森林地块。使用Begg\和Egger测试评估出版偏倚。使用Stata15进行所有分析,并且在p<0.05时考虑统计学显著性。
■一般来说，本分析包括9项研究.根据荟萃分析的结果，有流产和未流产的母亲之间锌水平的平均差异等于193.18（95％CI;107.11至279.25，P≤0.001）。换句话说,未流产母亲组的锌水平比流产母亲组高193个单位。根据Begg检验（P值=0.858）和Egger检验（P值=0.270），对有流产和无流产母亲的Zn水平比较的调查均未发现任何发表偏倚的迹象。
■研究结果表明，与未流产的母亲相比，流产母亲的锌含量较低之间存在显着关联。这表明，较高的锌水平可能对孕妇流产的发生具有预防作用。数据还突出了痕量金属的积极作用，特别是锌，在影响妊娠结局方面，并表明维持足够的锌水平可能会降低流产发生的可能性，以及其他促成因素。重要的是要注意，进一步的研究，包括前瞻性队列研究和实验研究，需要提供更多实质性证据并加强这些发现。
■本研究是对1980年至2022年在PubMed上发表的研究的系统回顾和荟萃分析，科学直接，专业任务,威利,WebofScience,和Scopus数据库。搜索使用main和Mesh关键字进行，专门针对与堕胎有关的术语，怀孕失败,和锌。使用卡方检验等统计检验评估荟萃分析中包含的研究中的异质性，I2和森林地块。使用Begg\和Egger测试评估出版偏倚。使用Stata15进行所有分析,并且在p<0.05时考虑统计学显著性。
■一般来说，本分析包括9项研究.根据荟萃分析的结果，有流产和未流产的母亲之间锌水平的平均差异等于193.18（95％CI;107.11至279.25，P≤0.001）。换句话说,未流产母亲组的锌水平比流产母亲组高193个单位。根据Begg检验（P值=0.858）和Egger检验（P值=0.270），对有流产和无流产母亲的Zn水平比较的调查均未发现任何发表偏倚的迹象。
■研究结果表明，与未流产的母亲相比，流产母亲的锌含量较低之间存在显着关联。这表明，较高的锌水平可能对孕妇流产的发生具有预防作用。数据还突出了痕量金属的积极作用，特别是锌，在影响妊娠结局方面，并表明维持足够的锌水平可能会降低流产发生的可能性，以及其他促成因素。重要的是要注意，进一步的研究，包括前瞻性队列研究和实验研究，需要提供更多实质性证据并加强这些发现。
