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Abstract：
UNASSIGNED: Sarcopenia and disability represent significant concerns impacting the health of older people. This study aimed to explore the bidirectional relationship between sarcopenia and disability in Chinese older people.
UNASSIGNED: This study recruited older people ≥60 years old from the China Health and Retirement Longitudinal Study. In phase I, the study analyzed the relation between disability and subsequent sarcopenia using multinomial logistic regression models. Conversely, in phase II, the study assessed whether sarcopenia was associated with future disability using binary logistic regression models.
UNASSIGNED: In phase I, 65 (16.80%) new cases of possible sarcopenia, 18 (4.65%) cases of sarcopenia, and 9 (2.33%) cases of severe sarcopenia were observed in the disabled older people and 282 (10.96%) new cases of possible sarcopenia, 97 (3.77%) cases of sarcopenia, 35 (1.36%) cases of severe sarcopenia were observed in the older people without disability. The OR (95% CI) for sarcopenia in older disabled individuals compared to those without disability was 1.61 (1.25-2.07). Adjusting for all covariates in 2011, the OR (95% CI) value for disabled individuals vs. those without disability was 1.35 (1.02-1.79). Subgroup analyses showed that disabled participants aged < 80 years were more likely to have sarcopenia (OR = 1.42, 95% CI: 1.07-1.89), and the risk of sarcopenia did not differ significantly between sex subgroups. In phase II, 114 cases (33.83%) in the possible sarcopenia patients, 85 cases (28.91%) in the sarcopenia patients, 23 cases (35.94%) in the severe sarcopenia patients, and 501 cases (16.10%) in the individuals without sarcopenia showed symptoms of disability. The OR (95% CI) for disability was 2.66 (2.08-3.40) in the possible sarcopenia patients, 2.12 (1.62-2.77) in the sarcopenia patients, and 2.92 (1.74-4.91) in the severe sarcopenia patients compared with the no sarcopenia patients. After adjusting for all covariates in 2011, the OR (95% CI) values were 2.21 (1.70-2.85) in the possible sarcopenia patients, 1.58 (1.14-2.19) in the sarcopenia patients, and 1.99 (1.14-3.49) in the severe sarcopenia patients, as compared to the older people without sarcopenia. Subgroup analyses showed that compared with men, women with possible sarcopenia had a higher risk of disability (OR = 2.80, 95% CI: 1.98-3.97). In addition, participants aged < 80 years with sarcopenia or severe sarcopenia s were more likely to have disability (OR = 2.13, 95% CI: 1.52-2.98; OR = 2.98, 95% CI: 1.60-5.54).
UNASSIGNED: The occurrence of disability increase the risk of sarcopenia in the older people, and baseline sarcopenia predicts the future disability in older people.
UNASSIGNED: This study recruited older people ≥60 years old from the China Health and Retirement Longitudinal Study. In phase I, the study analyzed the relation between disability and subsequent sarcopenia using multinomial logistic regression models. Conversely, in phase II, the study assessed whether sarcopenia was associated with future disability using binary logistic regression models.
UNASSIGNED: In phase I, 65 (16.80%) new cases of possible sarcopenia, 18 (4.65%) cases of sarcopenia, and 9 (2.33%) cases of severe sarcopenia were observed in the disabled older people and 282 (10.96%) new cases of possible sarcopenia, 97 (3.77%) cases of sarcopenia, 35 (1.36%) cases of severe sarcopenia were observed in the older people without disability. The OR (95% CI) for sarcopenia in older disabled individuals compared to those without disability was 1.61 (1.25-2.07). Adjusting for all covariates in 2011, the OR (95% CI) value for disabled individuals vs. those without disability was 1.35 (1.02-1.79). Subgroup analyses showed that disabled participants aged < 80 years were more likely to have sarcopenia (OR = 1.42, 95% CI: 1.07-1.89), and the risk of sarcopenia did not differ significantly between sex subgroups. In phase II, 114 cases (33.83%) in the possible sarcopenia patients, 85 cases (28.91%) in the sarcopenia patients, 23 cases (35.94%) in the severe sarcopenia patients, and 501 cases (16.10%) in the individuals without sarcopenia showed symptoms of disability. The OR (95% CI) for disability was 2.66 (2.08-3.40) in the possible sarcopenia patients, 2.12 (1.62-2.77) in the sarcopenia patients, and 2.92 (1.74-4.91) in the severe sarcopenia patients compared with the no sarcopenia patients. After adjusting for all covariates in 2011, the OR (95% CI) values were 2.21 (1.70-2.85) in the possible sarcopenia patients, 1.58 (1.14-2.19) in the sarcopenia patients, and 1.99 (1.14-3.49) in the severe sarcopenia patients, as compared to the older people without sarcopenia. Subgroup analyses showed that compared with men, women with possible sarcopenia had a higher risk of disability (OR = 2.80, 95% CI: 1.98-3.97). In addition, participants aged < 80 years with sarcopenia or severe sarcopenia s were more likely to have disability (OR = 2.13, 95% CI: 1.52-2.98; OR = 2.98, 95% CI: 1.60-5.54).
UNASSIGNED: The occurrence of disability increase the risk of sarcopenia in the older people, and baseline sarcopenia predicts the future disability in older people.
摘要：
■肌肉减少症和残疾是影响老年人健康的重大问题。本研究旨在探讨中国老年人肌肉减少症与残疾的双向关系。
■这项研究从中国健康与退休纵向研究中招募了≥60岁的老年人。在第一阶段,本研究使用多项logistic回归模型分析了残疾与随后的肌少症之间的关系.相反，在第二阶段，本研究使用二元logistic回归模型评估了肌肉减少症是否与未来残疾相关.
■在第一阶段，65例（16.80%）新发可能的肌少症病例，18例（4.65%）肌肉减少症，在残疾老年人中观察到9例（2.33％）严重的肌肉减少症和282例（10.96％）可能的肌肉减少症的新病例，97例（3.77%）肌肉减少症，在无残疾的老年人中观察到35例（1.36％）严重的肌肉减少症。老年残疾人与无残疾人相比，肌肉减少症的OR（95％CI）为1.61（1.25-2.07）。2011年调整所有协变量，残疾人的OR(95%CI)值与无残疾者为1.35（1.02-1.79）。亚组分析显示，年龄<80岁的残疾参与者更可能患有肌肉减少症（OR=1.42，95％CI：1.07-1.89），不同性别亚组之间的肌少症风险无显著差异.在第二阶段,114例(33.83%)在可能的肌少症患者中,85例(28.91%)在肌少症患者中,23例(35.94%)严重肌少症患者中,无肌少症患者中有501例(16.10%)出现残疾症状。在可能的肌少症患者中，残疾的OR（95％CI）为2.66（2.08-3.40），2.12（1.62-2.77）在肌肉减少症患者中，重度肌少症患者与无肌少症患者相比，为2.92（1.74-4.91）。在2011年调整所有协变量后，可能的肌少症患者的OR值（95％CI）为2.21（1.70-2.85），1.58（1.14-2.19）在肌肉减少症患者中，严重肌少症患者为1.99（1.14-3.49），与没有肌少症的老年人相比。亚组分析显示，与男性相比，可能患有肌少症的女性残疾风险较高(OR=2.80,95%CI:1.98~3.97).此外,年龄<80岁的肌少症患者或重度肌少症患者更容易出现残疾(OR=2.13,95%CI:1.52-2.98;OR=2.98,95%CI:1.60-5.54).
■残疾的发生会增加老年人肌肉减少症的风险，基线肌肉减少症预测老年人未来的残疾。
■这项研究从中国健康与退休纵向研究中招募了≥60岁的老年人。在第一阶段,本研究使用多项logistic回归模型分析了残疾与随后的肌少症之间的关系.相反，在第二阶段，本研究使用二元logistic回归模型评估了肌肉减少症是否与未来残疾相关.
■在第一阶段，65例（16.80%）新发可能的肌少症病例，18例（4.65%）肌肉减少症，在残疾老年人中观察到9例（2.33％）严重的肌肉减少症和282例（10.96％）可能的肌肉减少症的新病例，97例（3.77%）肌肉减少症，在无残疾的老年人中观察到35例（1.36％）严重的肌肉减少症。老年残疾人与无残疾人相比，肌肉减少症的OR（95％CI）为1.61（1.25-2.07）。2011年调整所有协变量，残疾人的OR(95%CI)值与无残疾者为1.35（1.02-1.79）。亚组分析显示，年龄<80岁的残疾参与者更可能患有肌肉减少症（OR=1.42，95％CI：1.07-1.89），不同性别亚组之间的肌少症风险无显著差异.在第二阶段,114例(33.83%)在可能的肌少症患者中,85例(28.91%)在肌少症患者中,23例(35.94%)严重肌少症患者中,无肌少症患者中有501例(16.10%)出现残疾症状。在可能的肌少症患者中，残疾的OR（95％CI）为2.66（2.08-3.40），2.12（1.62-2.77）在肌肉减少症患者中，重度肌少症患者与无肌少症患者相比，为2.92（1.74-4.91）。在2011年调整所有协变量后，可能的肌少症患者的OR值（95％CI）为2.21（1.70-2.85），1.58（1.14-2.19）在肌肉减少症患者中，严重肌少症患者为1.99（1.14-3.49），与没有肌少症的老年人相比。亚组分析显示，与男性相比，可能患有肌少症的女性残疾风险较高(OR=2.80,95%CI:1.98~3.97).此外,年龄<80岁的肌少症患者或重度肌少症患者更容易出现残疾(OR=2.13,95%CI:1.52-2.98;OR=2.98,95%CI:1.60-5.54).
■残疾的发生会增加老年人肌肉减少症的风险，基线肌肉减少症预测老年人未来的残疾。
