PDF(Pubmed)
Abstract：
L-type calcium channels (LTCCs), the largest subfamily of voltage-gated calcium channels (VGCCs), are the main channels for Ca2+ influx during extracellular excitation. LTCCs are widely present in excitable cells, especially cardiac and cardiovascular smooth muscle cells, and participate in various Ca2+-dependent processes. LTCCs have been considered as worthy drug target for cardiovascular, neurological and psychological diseases for decades. Natural products from Traditional Chinese medicine (TCM) have shown the potential as new drugs for the treatment of LTCCs related diseases. In this review, the basic structure, function of LTCCs, and the related human diseases caused by structural or functional abnormalities of LTCCs, and the natural LTCCs antagonist and their potential usages were summarized.
摘要：
L型钙通道（LTCC），电压门控钙通道（VGCC）的最大亚族，是细胞外激发过程中Ca2流入的主要通道。LTCC广泛存在于可兴奋细胞中，尤其是心脏和心血管平滑肌细胞，并参与各种依赖Ca2的过程。LTCC被认为是心血管疾病的有价值的药物靶标，几十年来神经和心理疾病。中药天然产物已显示出作为治疗LTCCs相关疾病的新药的潜力。在这次审查中,基本结构，LTCC的功能，以及由LTCC的结构或功能异常引起的相关人类疾病，总结了天然LTCCs拮抗剂及其潜在用途。
