PDF(Pubmed)
Abstract：
BACKGROUND: This study aims to investigate the factors affecting the vitreous levels of pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VGEF) among patients with pars plana vitrectomy (PPV). Also, this study correlates the levels of PEDF with RRD characteristics.
METHODS: All patients who were scheduled for PPV for any indication were included in the study. They were divided into a case group which included patients with advanced PDR and a control group which included the remaining diagnoses. During the PPV, an undiluted vitreous sample was taken and the enzyme-linked immunosorbent assay method was utilized to measure the levels of VEGF and PEDF.
RESULTS: Eighty eyes were involved. Patients diagnosed with advanced PDR and endophthalmitis exhibited higher levels of VEGF. PEDF was affected inversely by the age of the patients and PEDF levels were higher in RRD and endophthalmitis cases. In patients with RRD, the level of PEDF was higher if the tear was found inferiorly, if the macula was detached, and with a longer duration of RRD.
CONCLUSIONS: This study highlights the clinical importance of those biomarkers. Anti-VEGF-based treatment is the mainstay against PDR. PEDF may show a promising predictive values regarding patients with RRD.
METHODS: All patients who were scheduled for PPV for any indication were included in the study. They were divided into a case group which included patients with advanced PDR and a control group which included the remaining diagnoses. During the PPV, an undiluted vitreous sample was taken and the enzyme-linked immunosorbent assay method was utilized to measure the levels of VEGF and PEDF.
RESULTS: Eighty eyes were involved. Patients diagnosed with advanced PDR and endophthalmitis exhibited higher levels of VEGF. PEDF was affected inversely by the age of the patients and PEDF levels were higher in RRD and endophthalmitis cases. In patients with RRD, the level of PEDF was higher if the tear was found inferiorly, if the macula was detached, and with a longer duration of RRD.
CONCLUSIONS: This study highlights the clinical importance of those biomarkers. Anti-VEGF-based treatment is the mainstay against PDR. PEDF may show a promising predictive values regarding patients with RRD.
摘要：
背景：本研究的目的是探讨扁平部玻璃体切除术（PPV）患者玻璃体色素上皮衍生因子（PEDF）和血管内皮生长因子（VGEF）水平的影响因素。此外，本研究将PEDF水平与RRD特征相关联。
方法：所有因任何适应症而计划进行PPV的患者均纳入研究。他们被分为包括晚期PDR患者的病例组和包括其余诊断的对照组。在PPV期间，采集未稀释的玻璃体样品,采用酶联免疫吸附试验方法测定VEGF和PEDF水平.
结果：80只眼受累。诊断为晚期PDR和眼内炎的患者表现出更高水平的VEGF。PEDF受患者年龄的影响相反，RRD和眼内炎病例的PEDF水平较高。在RRD患者中，如果在下方发现撕裂，则PEDF的水平更高，如果黄斑脱落,并且具有较长的RRD持续时间。
结论：本研究强调了这些生物标志物的临床重要性。基于抗VEGF的治疗是抗PDR的主要方法。PEDF可能显示出有关RRD患者的有希望的预测值。
方法：所有因任何适应症而计划进行PPV的患者均纳入研究。他们被分为包括晚期PDR患者的病例组和包括其余诊断的对照组。在PPV期间，采集未稀释的玻璃体样品,采用酶联免疫吸附试验方法测定VEGF和PEDF水平.
结果：80只眼受累。诊断为晚期PDR和眼内炎的患者表现出更高水平的VEGF。PEDF受患者年龄的影响相反，RRD和眼内炎病例的PEDF水平较高。在RRD患者中，如果在下方发现撕裂，则PEDF的水平更高，如果黄斑脱落,并且具有较长的RRD持续时间。
结论：本研究强调了这些生物标志物的临床重要性。基于抗VEGF的治疗是抗PDR的主要方法。PEDF可能显示出有关RRD患者的有希望的预测值。
