PDF(Pubmed)
Abstract：
OBJECTIVE: to investigate the association between cartilage lesion-related features observed in knee osteoarthritis (OA) patients\' first MRI examination and incident knee surgery within 5 years. Additionally, to assess the predictive value of these features for the incident knee surgery.
METHODS: We identified patients diagnosed with knee OA and treated at our institution between January 2015 and January 2018, and retrieved their baseline clinical data and first MRI examination films from the information system. Next, we proceeded to determine joint space narrowing grade, cartilage lesion size grade, cartilage full-thickness loss grade and cartilage lesion sum score for the medial and lateral compartments, respectively. Generalized linear regression models examined the association of these features with 5-year incident knee surgery. Positive and negative predictive values (PPVs and NPVs) were determined referring to 5-year incident knee surgery.
RESULTS: Totally, 878 participants (knees) were found eligible to form the study population. Within the 5 years, surgery was performed on 61 knees. None of the cartilage-related features had been found significantly associated with incident surgery. The results were similar for medial and lateral compartments. The PPVs were low for all the features.
CONCLUSIONS: Among symptomatic clinically diagnosed OA knees, cartilage lesions observed in the first MRI examinations were not found to be associated with the occurrence of joint surgery within a 5-year period. All these cartilage-related features appear to have no additional value in predicting 5-year incident joint surgery.
METHODS: We identified patients diagnosed with knee OA and treated at our institution between January 2015 and January 2018, and retrieved their baseline clinical data and first MRI examination films from the information system. Next, we proceeded to determine joint space narrowing grade, cartilage lesion size grade, cartilage full-thickness loss grade and cartilage lesion sum score for the medial and lateral compartments, respectively. Generalized linear regression models examined the association of these features with 5-year incident knee surgery. Positive and negative predictive values (PPVs and NPVs) were determined referring to 5-year incident knee surgery.
RESULTS: Totally, 878 participants (knees) were found eligible to form the study population. Within the 5 years, surgery was performed on 61 knees. None of the cartilage-related features had been found significantly associated with incident surgery. The results were similar for medial and lateral compartments. The PPVs were low for all the features.
CONCLUSIONS: Among symptomatic clinically diagnosed OA knees, cartilage lesions observed in the first MRI examinations were not found to be associated with the occurrence of joint surgery within a 5-year period. All these cartilage-related features appear to have no additional value in predicting 5-year incident joint surgery.
摘要：
目的：探讨膝关节骨性关节炎（OA）患者5年内首次MRI检查与膝关节手术相关的软骨损伤特征之间的关系。此外,评估这些特征对膝关节手术的预测价值。
方法：我们确定了2015年1月至2018年1月在我们机构接受治疗的膝关节OA患者，并从信息系统中检索了他们的基线临床数据和第一份MRI检查片。接下来,我们继续确定关节空间变窄等级，软骨损伤大小等级,内侧和外侧隔室的软骨全厚度损失等级和软骨损伤总和评分，分别。广义线性回归模型检查了这些特征与5年膝关节手术的关联。参照5年的膝关节手术确定阳性和阴性预测值（PPV和NPV）。
结果：完全，878名参与者（膝盖）被发现有资格形成研究人群。五年之内,对61个膝盖进行了手术。没有发现与软骨相关的特征与手术发生显着相关。内侧和外侧隔室的结果相似。所有功能的PPV都很低。
结论：在有症状的临床诊断的OA膝关节中，首次MRI检查中观察到的软骨病变未发现与5年内关节手术的发生有关。所有这些与软骨相关的特征似乎在预测5年的意外关节手术中没有附加价值。
方法：我们确定了2015年1月至2018年1月在我们机构接受治疗的膝关节OA患者，并从信息系统中检索了他们的基线临床数据和第一份MRI检查片。接下来,我们继续确定关节空间变窄等级，软骨损伤大小等级,内侧和外侧隔室的软骨全厚度损失等级和软骨损伤总和评分，分别。广义线性回归模型检查了这些特征与5年膝关节手术的关联。参照5年的膝关节手术确定阳性和阴性预测值（PPV和NPV）。
结果：完全，878名参与者（膝盖）被发现有资格形成研究人群。五年之内,对61个膝盖进行了手术。没有发现与软骨相关的特征与手术发生显着相关。内侧和外侧隔室的结果相似。所有功能的PPV都很低。
结论：在有症状的临床诊断的OA膝关节中，首次MRI检查中观察到的软骨病变未发现与5年内关节手术的发生有关。所有这些与软骨相关的特征似乎在预测5年的意外关节手术中没有附加价值。
