PDF(Pubmed)
Abstract：
BACKGROUND: Chronic kidney disease (CKD) is a common postoperative complication in patients who undergo radical nephrectomy for renal tumours. However, the factors influencing long-term renal function require further investigation.
OBJECTIVE: This study was designed to investigate the trends in renal function changes and risk factors for renal function deterioration in renal tumour patients after radical nephrectomy.
METHODS: We monitored changes in renal function before and after surgery for 3 years. The progression of renal function was determined by the progression and degradation of CKD stages. Univariate and multivariate logistic regression analyses were used to analyse the causes of renal function progression.
RESULTS: We analysed the data of 329 patients with renal tumours who underwent radical nephrectomies between January 2013 and December 2018. In this study, 43.7% of patients had postoperative acute kidney injury (AKI), and 48.3% had CKD at advanced stages. Further research revealed that patients\' renal function stabilized 3 months after surgery. Additionally, renal function changes during these 3 months have a substantial impact on the progression of long-term renal function changes in patients.
CONCLUSIONS: AKI may be an indicator of short-term postoperative changes in renal function. Renal function tests should be performed in patients with AKI after radical nephrectomy to monitor the progression of functional impairment, particularly within the first 3 months after radical nephrectomy.
OBJECTIVE: This study was designed to investigate the trends in renal function changes and risk factors for renal function deterioration in renal tumour patients after radical nephrectomy.
METHODS: We monitored changes in renal function before and after surgery for 3 years. The progression of renal function was determined by the progression and degradation of CKD stages. Univariate and multivariate logistic regression analyses were used to analyse the causes of renal function progression.
RESULTS: We analysed the data of 329 patients with renal tumours who underwent radical nephrectomies between January 2013 and December 2018. In this study, 43.7% of patients had postoperative acute kidney injury (AKI), and 48.3% had CKD at advanced stages. Further research revealed that patients\' renal function stabilized 3 months after surgery. Additionally, renal function changes during these 3 months have a substantial impact on the progression of long-term renal function changes in patients.
CONCLUSIONS: AKI may be an indicator of short-term postoperative changes in renal function. Renal function tests should be performed in patients with AKI after radical nephrectomy to monitor the progression of functional impairment, particularly within the first 3 months after radical nephrectomy.
摘要：
背景：慢性肾脏病（CKD）是接受根治性肾切除术治疗肾肿瘤的患者常见的术后并发症。然而,影响长期肾功能的因素需要进一步研究.
目的：本研究旨在探讨肾肿瘤患者根治性肾切除术后肾功能的变化趋势和肾功能恶化的危险因素。
方法：我们监测手术前后肾功能的变化，为期3年。肾功能的进展取决于CKD分期的进展和退化。使用单变量和多变量逻辑回归分析来分析肾功能进展的原因。
结果：我们分析了在2013年1月至2018年12月期间接受根治性肾切除术的329例肾肿瘤患者的数据。在这项研究中,43.7％的患者发生术后急性肾损伤（AKI），和48.3％的CKD在晚期。进一步的研究表明，患者的肾功能在手术后3个月稳定。此外,这3个月期间的肾功能变化对患者长期肾功能变化的进展有重大影响.
结论：AKI可能是术后肾功能短期变化的指标。对根治性肾切除术后AKI患者应进行肾功能检查，以监测功能损害的进展，特别是在根治性肾切除术后的前3个月内。
目的：本研究旨在探讨肾肿瘤患者根治性肾切除术后肾功能的变化趋势和肾功能恶化的危险因素。
方法：我们监测手术前后肾功能的变化，为期3年。肾功能的进展取决于CKD分期的进展和退化。使用单变量和多变量逻辑回归分析来分析肾功能进展的原因。
结果：我们分析了在2013年1月至2018年12月期间接受根治性肾切除术的329例肾肿瘤患者的数据。在这项研究中,43.7％的患者发生术后急性肾损伤（AKI），和48.3％的CKD在晚期。进一步的研究表明，患者的肾功能在手术后3个月稳定。此外,这3个月期间的肾功能变化对患者长期肾功能变化的进展有重大影响.
结论：AKI可能是术后肾功能短期变化的指标。对根治性肾切除术后AKI患者应进行肾功能检查，以监测功能损害的进展，特别是在根治性肾切除术后的前3个月内。
