PDF(Pubmed)
Abstract：
BACKGROUND: Lymph node (LN) status is an important prognostic factor for parotid gland cancer (PGC). This study aimed to analyze the impact of extranodal extension (ENE) of intraparotid LN and LN metastasis burden on survival in PGC.
METHODS: Patients with surgically treated PGC and at least one metastatic cervical LN were retrospectively enrolled. Primary outcome variables were distant metastasis-free survival (DMFS), disease-specific survival (DSS), and overall survival (OS). The impact of ENE and LN metastasis burden was assessed using the Cox model.
RESULTS: A total of 292 patients were included. ENE in cervical or intraparotid LN was not associated with DMFS, DSS, or OS. Intraparotid LN metastasis had a significant impact on prognosis, and the presence of only one metastatic intraparotid LN offered an approximately 1.5-fold risk of distant metastasis. Prognostic models based on the number of positive LNs (1 vs. 2-3 vs. 4+) were superior to the AJCC N stage in terms of DMFS, DSS, and OS.
CONCLUSIONS: ENE of cervical or intraparotid LN has a limited effect on the prognosis of PGC, and the number of positive LNs is better than the AJCC N stage in LN status evaluation.
METHODS: Patients with surgically treated PGC and at least one metastatic cervical LN were retrospectively enrolled. Primary outcome variables were distant metastasis-free survival (DMFS), disease-specific survival (DSS), and overall survival (OS). The impact of ENE and LN metastasis burden was assessed using the Cox model.
RESULTS: A total of 292 patients were included. ENE in cervical or intraparotid LN was not associated with DMFS, DSS, or OS. Intraparotid LN metastasis had a significant impact on prognosis, and the presence of only one metastatic intraparotid LN offered an approximately 1.5-fold risk of distant metastasis. Prognostic models based on the number of positive LNs (1 vs. 2-3 vs. 4+) were superior to the AJCC N stage in terms of DMFS, DSS, and OS.
CONCLUSIONS: ENE of cervical or intraparotid LN has a limited effect on the prognosis of PGC, and the number of positive LNs is better than the AJCC N stage in LN status evaluation.
摘要：
背景：淋巴结（LN）状态是腮腺腺癌（PGC）的重要预后因素。本研究旨在分析颈动脉内LN的结外延伸（ENE）和LN转移负荷对PGC患者生存的影响。
方法：回顾性纳入经手术治疗的PGC和至少1例转移性宫颈LN患者。主要结果变量为无远处转移生存期（DMFS），疾病特异性生存率（DSS），总生存率（OS）。使用Cox模型评估ENE和LN转移负荷的影响。
结果：共纳入292例患者。宫颈或颈动脉LN中的ENE与DMFS无关，DSS,或操作系统。颈动脉内LN转移对预后有显著影响,而仅有1例转移性颈动脉内LN的存在,导致远处转移的风险约为1.5倍.基于正LN数量的预后模型（1与2-3vs.4+)在DMFS方面优于AJCCN阶段，DSS,和OS。
结论：颈内或颈内LN的ENE对PGC的预后影响有限，在LN状态评估中，阳性LN的数量优于AJCCN阶段。
方法：回顾性纳入经手术治疗的PGC和至少1例转移性宫颈LN患者。主要结果变量为无远处转移生存期（DMFS），疾病特异性生存率（DSS），总生存率（OS）。使用Cox模型评估ENE和LN转移负荷的影响。
结果：共纳入292例患者。宫颈或颈动脉LN中的ENE与DMFS无关，DSS,或操作系统。颈动脉内LN转移对预后有显著影响,而仅有1例转移性颈动脉内LN的存在,导致远处转移的风险约为1.5倍.基于正LN数量的预后模型（1与2-3vs.4+)在DMFS方面优于AJCCN阶段，DSS,和OS。
结论：颈内或颈内LN的ENE对PGC的预后影响有限，在LN状态评估中，阳性LN的数量优于AJCCN阶段。
