METHODS: Patients with surgically treated PGC and at least one metastatic cervical LN were retrospectively enrolled. Primary outcome variables were distant metastasis-free survival (DMFS), disease-specific survival (DSS), and overall survival (OS). The impact of ENE and LN metastasis burden was assessed using the Cox model.
RESULTS: A total of 292 patients were included. ENE in cervical or intraparotid LN was not associated with DMFS, DSS, or OS. Intraparotid LN metastasis had a significant impact on prognosis, and the presence of only one metastatic intraparotid LN offered an approximately 1.5-fold risk of distant metastasis. Prognostic models based on the number of positive LNs (1 vs. 2-3 vs. 4+) were superior to the AJCC N stage in terms of DMFS, DSS, and OS.
CONCLUSIONS: ENE of cervical or intraparotid LN has a limited effect on the prognosis of PGC, and the number of positive LNs is better than the AJCC N stage in LN status evaluation.
方法:回顾性纳入经手术治疗的PGC和至少1例转移性宫颈LN患者。主要结果变量为无远处转移生存期(DMFS),疾病特异性生存率(DSS),总生存率(OS)。使用Cox模型评估ENE和LN转移负荷的影响。
结果:共纳入292例患者。宫颈或颈动脉LN中的ENE与DMFS无关,DSS,或操作系统。颈动脉内LN转移对预后有显著影响,而仅有1例转移性颈动脉内LN的存在,导致远处转移的风险约为1.5倍.基于正LN数量的预后模型(1与2-3vs.4+)在DMFS方面优于AJCCN阶段,DSS,和OS。
结论:颈内或颈内LN的ENE对PGC的预后影响有限,在LN状态评估中,阳性LN的数量优于AJCCN阶段。