Abstract：
Bedsores impose an important challenge to the healthcare system. Se-baring probiotics are considered effective agents in wound healing and inflammation reduction via several pathways. The present study focused on the administration of a Se-enriched probiotic, originally obtained from a traditional dairy product for bedsore healing. Daily doses of the probiotic were administered to 20 ICU patients for 14 days and the wound healing criteria were compared with those of the same group of ICU patients as control, both groups suffering from stages I and II bedsore (a randomized, double-blind, controlled clinical trial). The administered Se-enriched probiotic decreased the bedsore healing period significantly (on average by 2.4 days, P-value: 0.039), as well as bedsore size (on average by 7 mm2, nonsignificant) and bedsore grade (10%, nonsignificant) in the treatment group more efficiently than the control group. Some key laboratory parameters associated with inflammation were also improved in patients receiving the Se-supplemented probiotic. The limitations of this study include the low number of patients meeting inclusion criteria within the timeframe of the study, and the impossibility of following up patients after discharge from the ICU. In summary, this study revealed the effectiveness of the Se-enriched probiotic in bedsore improvement, suggesting consideration of the enriched probiotic as an auxiliary agent in bedsore management.
摘要：
褥疮对医疗保健系统构成了重要挑战。硒化益生菌被认为是通过几种途径在伤口愈合和炎症减少中的有效试剂。本研究集中在富含硒的益生菌的管理，最初是从传统乳制品中获得的，用于治疗褥疮。每天给20名ICU患者服用益生菌14天，并将伤口愈合标准与对照组的ICU患者进行比较。两组都患有Ⅰ期和Ⅱ期褥疮(随机，双盲,对照临床试验)。施用的富硒益生菌显着降低了褥疮愈合期（平均2.4天，P值:0.039),以及褥疮大小(平均7平方毫米，不显著)和褥疮等级(10%，无显著性)治疗组比对照组更有效。在接受硒补充益生菌的患者中,与炎症相关的一些关键实验室参数也得到改善。这项研究的局限性包括在研究的时间范围内符合纳入标准的患者数量少，以及从ICU出院后无法对患者进行随访。总之,这项研究揭示了富硒益生菌在改善褥疮方面的有效性，建议考虑将富含益生菌作为褥疮管理的辅助药物。
