RESULTS: Significant linear correlations were observed between known fat content (FC) and VNI for pure fat phantoms (r = 0.981-0.999, p < 0.001) and between known iron content (IC) and VIC for pure iron phantoms (r = 0.897-0.975, p < 0.001). In fat-iron phantoms, the measurement for fat content of 5-30% demonstrated good linearity between FC and VNI (r = 0.919-0.990, p < 0.001), and VNI were not affected by 75, 150, and 225 µmol/g iron overload (p = 0.174-0.519). The measurement for iron demonstrated a linear range of 75-225 µmol/g between IC and VIC (r = 0.961-0.994, p < 0.001) and VIC was not confounded by the coexisting 5%, 20%, and 30% fat deposition (p = 0.943-0.999). The Bland-Altman of fat and iron measurements were not significantly different at varying tube voltages and IQ settings (all p > 0.05). No significant difference in VNI and VIC at QIR 1-4.
CONCLUSIONS: PCD CT can accurately and simultaneously quantify fat and iron, including scan parameters with lower radiation dose.
结果:在纯脂肪模型的已知脂肪含量(FC)和VNI之间观察到显着的线性相关性(r=0.981-0.999,p<0.001),在已知铁含量(IC)和VIC之间观察到纯铁模型(r=0.897-0.975,p<0.001)。在脂肪铁幻影中,5-30%的脂肪含量的测量表明FC和VNI之间具有良好的线性(r=0.919-0.990,p<0.001),和VNI不受75、150和225µmol/g铁过载的影响(p=0.174-0.519)。铁的测量表明,IC和VIC之间的线性范围为75-225µmol/g(r=0.961-0.994,p<0.001),VIC未被共存的5%混淆,20%,和30%的脂肪沉积(p=0.943-0.999)。在不同的管电压和IQ设置下,脂肪和铁的Bland-Altman测量值没有显着差异(所有p>0.05)。在QIR1-4时,VNI和VIC没有显着差异。
结论:PCDCT能准确、同时定量脂肪和铁,包括辐射剂量较低的扫描参数。