Abstract：
Poly(3, 4-ethylenedioxythiophene) (PEDOT) as a new generation of intelligent conductive polymers, is attracting much attention in the field of tissue engineering. However, its water dispersibility, conductivity, and biocompatibility are incompatible, which limit its further development. In this work, biocompatible electrode material of PEDOT doped with sodium sulfonated alginate (SS) which contains two functional groups of sulfonic acid and carboxylic acid per repeat unit of the macromolecule. The as dual-site doping strategy simultaneously boosts anticoagulant and electrochemical performances, for example, good hydrophilicity (water contact angle of 59.40°), well dispersibility (dispersion solution unstratified in 30 days), high conductivity (4.45 S m-1), and enhanced anticoagulant property (extended activated partial thrombin time value of 59.0 s), forming an adjustable PEDOT: biomacromolecule interface; this fills the technical gap of implantable bioelectronics in terms of coagulation and thrombosis risk. At the same time, the assembled all-in-one supercapacitor with anticoagulant properties is prepared by PEDOT: sodium sulfonated alginate as electrode material and sodium alginate hydrogel as electrolyte layer. The dual-site doping strategy provides a new opinion for the design and optimization of functional conductive polymers and its applications in implantable energy storage fields.
摘要：
聚(3,4-亚乙基二氧噻吩)作为新一代智能导电聚合物,在组织工程领域备受关注。然而,它的水分散性，电导率，和生物相容性是不相容的，这限制了它的进一步发展。在这项工作中,由磺化藻酸钠掺杂的聚（3，4-亚乙基二氧噻吩）的生物相容性电极材料，每个大分子重复单元包含两个磺酸和羧酸官能团。作为双位点掺杂策略同时提高抗凝血和电化学性能，例如，良好的亲水性（水接触角为59.40°），良好的分散性(分散溶液在30天内未分层)，高电导率（4.45S·m-1），和增强的抗凝血性能（延长APTT值59.0s），形成可调节的聚（3，4-亚乙基二氧噻吩）：生物大分子界面；这填补了可植入生物电子学在凝血和血栓形成风险方面的技术空白。同时,以聚（3，4-亚乙基二氧噻吩）：磺化海藻酸钠为电极材料，海藻酸钠水凝胶为电解质层，制备了具有抗凝血性能的多合一超级电容器。双位点掺杂策略为功能性导电聚合物的设计和优化及其在植入式储能领域的应用提供了新的见解。本文受版权保护。保留所有权利。
