Abstract：
We assessed the efficiency of intravenous adjuvants in decreasing opioid intake and pain scores after spine fusion surgery.
This study included 120 patients aged 18-60 listed for spine fusion surgery under general anesthesia. Patients were randomly assigned to four groups: Group (Lidocaine): received IV lidocaine 4 mg/kg in 50 mL volume over 30 min. Group (Magnesium): received IV magnesium sulfate 30mg/kg in 50 mL volume over 30 min. Group (combined Lidocaine and Magnesium): received IV lidocaine 4 mg/kg in 50 mL volume over 30 min.+IV magnesium sulfate 30mg/kg in 50 mL volume over 30 min. Group (Control): received IV saline 50 mL. The time to the first request analgesia, the postoperative pain score, total analgesic use, patient satisfaction, anxiety, depression, mental state, quality of life, and side effects were measured.
The combined group had more extended time for the first analgesic request and fewer rescue analgesia doses than the other groups. NRS scores at rest or movement were statistically significantly lower in the lidocaine group and the combined group compared to the control group (P1, P3<0.05) at almost all times. This combination reduces anxiety and depression and improves overall health up to three months after a single infusion. The combined group had higher patient satisfaction.
A synergistic effect of a combination of lidocaine and magnesium sulfate on perioperative pain was found. It reduces analgesic consumption, depression, and anxiety and improves overall health up to three months after a single infusion dose.
This study included 120 patients aged 18-60 listed for spine fusion surgery under general anesthesia. Patients were randomly assigned to four groups: Group (Lidocaine): received IV lidocaine 4 mg/kg in 50 mL volume over 30 min. Group (Magnesium): received IV magnesium sulfate 30mg/kg in 50 mL volume over 30 min. Group (combined Lidocaine and Magnesium): received IV lidocaine 4 mg/kg in 50 mL volume over 30 min.+IV magnesium sulfate 30mg/kg in 50 mL volume over 30 min. Group (Control): received IV saline 50 mL. The time to the first request analgesia, the postoperative pain score, total analgesic use, patient satisfaction, anxiety, depression, mental state, quality of life, and side effects were measured.
The combined group had more extended time for the first analgesic request and fewer rescue analgesia doses than the other groups. NRS scores at rest or movement were statistically significantly lower in the lidocaine group and the combined group compared to the control group (P1, P3<0.05) at almost all times. This combination reduces anxiety and depression and improves overall health up to three months after a single infusion. The combined group had higher patient satisfaction.
A synergistic effect of a combination of lidocaine and magnesium sulfate on perioperative pain was found. It reduces analgesic consumption, depression, and anxiety and improves overall health up to three months after a single infusion dose.
摘要：
背景：我们评估了静脉内佐剂在脊柱融合术后降低阿片类药物摄入量和疼痛评分的有效性。
方法：本研究纳入了120名年龄在18-60岁的患者，在全身麻醉下进行脊柱融合手术。患者被随机分为四组：组（利多卡因）：在30分钟内，以50mL的体积接受4mg/kg的利多卡因。组(镁):经30分钟以50mL体积接受静脉内硫酸镁30mg/kg。组(联合利多卡因和镁):在30分钟内接受以50mL体积的IV利多卡因4mg/kg。+IV硫酸镁30mg/kg在50mL体积超过30分钟。组(对照组):接受IV盐水50mL。第一次要求镇痛的时间，术后疼痛评分,总镇痛药使用，患者满意度,焦虑,抑郁症,精神状态,生活质量,并测量了副作用。
结果：联合组比其他组首次镇痛请求时间延长，抢救镇痛剂量较少。与对照组相比，利多卡因组和联合组的休息或运动时的NRS评分在几乎所有时间均具有统计学意义（P1，P3<0.05）。这种组合可以减少焦虑和抑郁，并在单次输注后三个月内改善整体健康状况。联合组患者满意度较高。
结论：发现利多卡因和硫酸镁联合治疗围手术期疼痛具有协同作用。它减少了镇痛药的消耗，抑郁症,和焦虑和改善整体健康状况长达三个月后单次输注剂量。
方法：本研究纳入了120名年龄在18-60岁的患者，在全身麻醉下进行脊柱融合手术。患者被随机分为四组：组（利多卡因）：在30分钟内，以50mL的体积接受4mg/kg的利多卡因。组(镁):经30分钟以50mL体积接受静脉内硫酸镁30mg/kg。组(联合利多卡因和镁):在30分钟内接受以50mL体积的IV利多卡因4mg/kg。+IV硫酸镁30mg/kg在50mL体积超过30分钟。组(对照组):接受IV盐水50mL。第一次要求镇痛的时间，术后疼痛评分,总镇痛药使用，患者满意度,焦虑,抑郁症,精神状态,生活质量,并测量了副作用。
结果：联合组比其他组首次镇痛请求时间延长，抢救镇痛剂量较少。与对照组相比，利多卡因组和联合组的休息或运动时的NRS评分在几乎所有时间均具有统计学意义（P1，P3<0.05）。这种组合可以减少焦虑和抑郁，并在单次输注后三个月内改善整体健康状况。联合组患者满意度较高。
结论：发现利多卡因和硫酸镁联合治疗围手术期疼痛具有协同作用。它减少了镇痛药的消耗，抑郁症,和焦虑和改善整体健康状况长达三个月后单次输注剂量。
