PDF(Pubmed)
Abstract：
BACKGROUND: This study aims to explore the effect of nutritional impact symptoms (NIS) on oral nutritional supplements (ONS) energy intake and use days among head and neck cancer (HNC) patients.
METHODS: A cross-sectional study was conducted among HNC patients in a hospital in western China between January 2019 and June 2020. The NIS was from the Patient-Generated Subjective Global Assessment (PG-SGA) scale. Mann-Whitney test was used to examine the differences between different kinds of NIS and ONS use days. Binary logistic regression was used to determine the effect of NIS on ONS energy intake.
RESULTS: The most prevalent four NIS were no appetite (35.3%), dysphagia (29.4%), vomiting (13.2%) and oral pain (12.5%), respectively. All patients in the study were malnutrition. Patients with xerostomia or oral pain had less ONS use days than those without these symptoms. Patients with vomiting (OR 0.09, 95% CI 0.02-0.50) or pain (OR 0.15, 95% CI 0.02-0.89) were less likely to have ONS energy intake ≥400 kcal/day than those without these symptoms after adjusting the confounding factors. In addition, one-point increase in total NIS score was associated with a lower proportion of ONS energy intake ≥400 kcal/day (OR 0.77, 95% CI 0.59-0.99).
CONCLUSIONS: Xerostomia, oral pain, vomiting and pain should be strengthened and intervened to improve ONS use and nutritional status among HNC patients with malnutrition.
METHODS: A cross-sectional study was conducted among HNC patients in a hospital in western China between January 2019 and June 2020. The NIS was from the Patient-Generated Subjective Global Assessment (PG-SGA) scale. Mann-Whitney test was used to examine the differences between different kinds of NIS and ONS use days. Binary logistic regression was used to determine the effect of NIS on ONS energy intake.
RESULTS: The most prevalent four NIS were no appetite (35.3%), dysphagia (29.4%), vomiting (13.2%) and oral pain (12.5%), respectively. All patients in the study were malnutrition. Patients with xerostomia or oral pain had less ONS use days than those without these symptoms. Patients with vomiting (OR 0.09, 95% CI 0.02-0.50) or pain (OR 0.15, 95% CI 0.02-0.89) were less likely to have ONS energy intake ≥400 kcal/day than those without these symptoms after adjusting the confounding factors. In addition, one-point increase in total NIS score was associated with a lower proportion of ONS energy intake ≥400 kcal/day (OR 0.77, 95% CI 0.59-0.99).
CONCLUSIONS: Xerostomia, oral pain, vomiting and pain should be strengthened and intervened to improve ONS use and nutritional status among HNC patients with malnutrition.
摘要：
背景：本研究旨在探讨营养影响症状（NIS）对头颈部癌症（HNC）患者口服营养补充剂（ONS）能量摄入和使用天数的影响。
方法：在2019年1月至2020年6月期间，对中国西部某医院的HNC患者进行了一项横断面研究。NIS来自患者主观整体评估(PG-SGA)量表。Mann-Whitney检验用于检查不同类型的NIS和ONS使用天数之间的差异。二元逻辑回归用于确定NIS对ONS能量摄入的影响。
结果：最普遍的四种NIS是无食欲（35.3%），吞咽困难（29.4%），呕吐(13.2%)和口腔疼痛(12.5%),分别。研究中所有患者均为营养不良。口干症或口腔疼痛患者的ONS使用天数少于没有这些症状的患者。在调整混杂因素后，有呕吐（OR0.09，95％CI0.02-0.50）或疼痛（OR0.15，95％CI0.02-0.89）的患者与没有这些症状的患者相比，ONS能量摄入≥400kcal/天的可能性较小。此外,NIS总分增加1分与ONS能量摄入≥400kcal/天的比例降低相关(OR0.77,95%CI0.59-0.99).
结论：口干症，口腔疼痛,应加强呕吐和疼痛干预，以改善营养不良的HNC患者使用ONS和营养状况。
方法：在2019年1月至2020年6月期间，对中国西部某医院的HNC患者进行了一项横断面研究。NIS来自患者主观整体评估(PG-SGA)量表。Mann-Whitney检验用于检查不同类型的NIS和ONS使用天数之间的差异。二元逻辑回归用于确定NIS对ONS能量摄入的影响。
结果：最普遍的四种NIS是无食欲（35.3%），吞咽困难（29.4%），呕吐(13.2%)和口腔疼痛(12.5%),分别。研究中所有患者均为营养不良。口干症或口腔疼痛患者的ONS使用天数少于没有这些症状的患者。在调整混杂因素后，有呕吐（OR0.09，95％CI0.02-0.50）或疼痛（OR0.15，95％CI0.02-0.89）的患者与没有这些症状的患者相比，ONS能量摄入≥400kcal/天的可能性较小。此外,NIS总分增加1分与ONS能量摄入≥400kcal/天的比例降低相关(OR0.77,95%CI0.59-0.99).
结论：口干症，口腔疼痛,应加强呕吐和疼痛干预，以改善营养不良的HNC患者使用ONS和营养状况。
