Abstract：
Five undescribed meroterpenoids, baosglucidnes A - E (1-5), were isolated from the fruiting bodies of Ganoderma lucidum. Among them, baosglucidne B (2) as a racemic mixture was obtained. Chiral HPLC was employed to separate a pair of enantiomers (+)-2 and (-)-2. The structures and stereochemical features of these substances were characterized by utilizing spectroscopic data and ECD calculations. Finally, the results of anti-renal fibrosis activity evaluation showed that baosglucidne E (5) could inhibit the expression of collagen I in TGF-β1-induced rat kidney proximal tubular cells at 20 μM.
摘要：
五种未被描述的黄酮类化合物，鲍斯葡萄糖苷A-E(1-5)，从灵芝子实体中分离出来。其中,获得外消旋混合物形式的baosglucidneB(2)。使用手性HPLC分离一对对映异构体(+)-2和(-)-2。通过利用光谱数据和ECD计算来表征这些物质的结构和立体化学特征。最后,抗肾纤维化活性评价结果显示,鲍斯葡萄糖苷E(5)在20μM时可抑制TGF-β1诱导的大鼠肾近端肾小管细胞胶原I的表达。
