%0 Journal Article
%T Five undescribed meroterpenoids from Ganoderma lucidum and their inhibitory activities against renal fibrosis.
%A Li D
%A Gao Q
%A Cheng YX
%A Luo Q
%J Fitoterapia
%V 176
%N 0
%D 2024 Jul 19
%M 38768793
%F 3.204
%R 10.1016/j.fitote.2024.106031
%X Five undescribed meroterpenoids, baosglucidnes A - E (1-5), were isolated from the fruiting bodies of Ganoderma lucidum. Among them, baosglucidne B (2) as a racemic mixture was obtained. Chiral HPLC was employed to separate a pair of enantiomers (+)-2 and (-)-2. The structures and stereochemical features of these substances were characterized by utilizing spectroscopic data and ECD calculations. Finally, the results of anti-renal fibrosis activity evaluation showed that baosglucidne E (5) could inhibit the expression of collagen I in TGF-β1-induced rat kidney proximal tubular cells at 20 μM.