Abstract：
From ancient times to the present, parasites and the diseases they transmit have jeopardized the health and wellbeing of working and companion canines worldwide. Many common pests that afflict dogs can be classified as ectoparasites (e.g., fleas, ticks, lice), which serve as vectors of pathogens transmitted as the organism feeds or defecates; or endoparasites (e. g, helminths, protozoa), which can cause slowly progressive subclinical canine diseases as well as acute illnesses associated with high morbidity and mortality rates. Safe, effective antiparasitic prophylaxis in dogs remains a topic of major interest to both veterinarians and their clients, especially with respect to the prevention of canine heartworm infection and flea or tick infestation. Many compounders, especially those whose pharmacy includes a retail component, counsel veterinarians and pet owners about preparations and commercially available medications that prevent or treat parasitic infestations and provide assistance in obtaining those therapies. To support such efforts, this article provides information about single agents and combination-drug products prophylactic against common canine parasites, emerging resistance to those medications, and the toxic effects that such treatments can engender in some canine breeds.
摘要：
从古至今,寄生虫及其传播的疾病危害了全世界工作犬和伴侣犬的健康和福祉。许多折磨狗的常见害虫可以归类为体外寄生虫(例如，跳蚤,蜱,虱子),作为病原体的载体，作为生物体的饲料或排便传播；或内寄生虫（例如g,蠕虫,原生动物)，这可能导致缓慢进展的亚临床犬病以及与高发病率和死亡率相关的急性疾病。安全,在狗中有效的抗寄生虫预防仍然是兽医及其客户的主要兴趣话题，特别是在预防犬心丝虫感染和跳蚤或蜱虫感染方面。许多混合者，尤其是那些药房包括零售成分的人，就预防或治疗寄生虫感染的制剂和市售药物向兽医和宠物主人提供咨询，并为获得这些疗法提供帮助。为了支持这种努力，本文提供了有关预防常见犬寄生虫的单一药物和联合药物产品的信息，出现对这些药物的耐药性，以及这种治疗方法可能在某些犬科动物中产生的毒性作用。
