链烯基羟吲哚是一种新的 PROTAC 部分, 其募集 CRL4DCAF11 E3 泛素连接酶复合物用于靶向蛋白质降解。
Mesh : Humans Animals Proteolysis / drug effects Mice Ubiquitin-Protein Ligases / metabolism Oxindoles / pharmacology metabolism chemistry Cell Cycle Proteins / metabolism Transcription Factors / metabolism Cell Line, Tumor Xenograft Model Antitumor Assays Mice, Nude HEK293 Cells Structure-Activity Relationship Proteasome Endopeptidase Complex / metabolism Azepines / pharmacology chemistry metabolism Antineoplastic Agents / pharmacology chemistry Female Bromodomain Containing Proteins Receptors, Interleukin-17
来 源:
DOI:10.1371/journal.pbio.3002550
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