Abstract：
Melanoma, with its diverse histopathologic characteristics, can mimic both benign nevi and neoplasms of various cell lineages. Immunohistochemistry (IHC) can play a vital role in melanoma diagnosis, particularly when the cell lineage is unclear on hematoxylin and eosin sections. Commonly utilized IHC stains for melanoma diagnosis include SOX10, Melan-A, and S100. A relatively novel stain, PReferentially expressed Antigen in MElanoma (PRAME), is also proving useful in accurate melanoma diagnosis. However, none of these stains are completely specific to melanocytes or melanoma, and misinterpretation can lead to incorrect diagnoses. This report presents a unique case of triple-negative breast carcinoma (TNBC) metastatic to the skin exhibiting histopathologic characteristics similar to melanoma, including positivity for SOX10 and PRAME. Our aim is to highlight TNBC metastatic to the skin as a potential diagnostic pitfall.
摘要：
黑色素瘤,具有不同的组织病理学特征，可以模拟良性痣和各种细胞谱系的肿瘤。免疫组织化学(IHC)在黑色素瘤的诊断中发挥着至关重要的作用,特别是当苏木精和伊红切片的细胞谱系不清楚时。用于黑色素瘤诊断的常用IHC染色包括SOX10，Melan-A，S100一个相对新颖的污点，在MELanoma（PRAME）中优先表达的抗原，在准确的黑色素瘤诊断中也被证明是有用的。然而,这些染色都不是黑素细胞或黑色素瘤完全特有的，和误解会导致错误的诊断。本报告介绍了三阴性乳腺癌（TNBC）转移到皮肤的独特病例，其组织病理学特征与黑色素瘤相似。包括SOX10和PRAME的积极性。我们的目标是强调TNBC转移到皮肤作为潜在的诊断陷阱。
