Abstract：
Amphibians are well-known for their ability to produce and secrete a mixture of bioactive substances in specialized skin glands for the purpose of antibiotic self-protection and defense against predators. Some of these secretions contain various small molecules, such as the highly toxic batrachotoxin, tetrodotoxin, and samandarine. For some time, the presence of peptides in amphibian skin secretions has attracted researchers, consisting of a diverse collection of - to the current state of knowledge - three to 104 amino acid long sequences. From these more than 2000 peptides many are known to exert antimicrobial effects. In addition, there are some reports on amphibian skin peptides that can promote wound healing, regulate immunoreactions, and may serve as antiparasitic and antioxidative substances. So far, the focus has mainly been on skin peptides from frogs and toads (Anura), eclipsing the research on skin peptides of the ca. 700 salamanders and newts (Caudata). Just recently, several novel observations dealing with caudate peptides and their structure-function relationships were reported. This review focuses on the chemistry and bioactivity of caudate amphibian skin peptides and their potential as novel agents for clinical applications.
摘要：
两栖动物以其在专门的皮肤腺体中产生和分泌生物活性物质混合物的能力而闻名，用于抗生素自我保护和防御掠食者。其中一些分泌物含有各种小分子，比如剧毒的细菌毒素，河豚毒素,还有Samandarine.有一段时间,两栖动物皮肤分泌物中肽的存在吸引了研究人员，由不同的集合组成-到目前的知识状态-3到104个氨基酸长的序列。从这些超过2000个肽中已知许多发挥抗微生物作用。此外,有一些关于两栖动物皮肤肽可以促进伤口愈合的报道，调节免疫反应，并可作为抗寄生虫和抗氧化物质。到目前为止,重点主要是来自青蛙和蟾蜍（Anura）的皮肤肽，使ca皮肤肽的研究黯然失色。700只sal和new（Caudata）。就在最近,报道了一些关于尾状肽及其结构-功能关系的新观察。这篇综述的重点是尾状两栖动物皮肤肽的化学和生物活性及其作为临床应用的新型药物的潜力。
