PDF(Pubmed)
Abstract：
UNASSIGNED: Influenza and COVID-19 patients share similar features and outcomes amongst adults. However, the difference between these diseases is not explored in paediatric age group especially in terms of inflammatory markers, coagulation profile and outcomes. Hence, we did this review to compare the inflammatory, coagulation features and outcomes between influenza and COVID-19 infected children.
UNASSIGNED: Literature search was done in PubMed Central, Scopus, EMBASE, CINAHL, Cochrane library, Google Scholar & ScienceDirect from November 2019 to May 2022. Risk of bias assessment was done through Newcastle Ottawa scale. Meta-analysis was done using random-effects model and the final pooled estimate was reported as pooled odds ratio (OR) or standardized mean difference (SMD) along with 95 % confidence interval (CI) depending on the type of outcome.
UNASSIGNED: About 16 studies were included with most studies having higher risk of bias. Influenza paediatric patients had significantly higher erythrocyte sedimentation rate (ESR) (pooled SMD = 0.60; 95%CI: 0.30-0.91; I2 = 0 %), lactate dehydrogenase (LDH) (pooled SMD = 2.01; 95%CI: 0.37-3.66; I2 = 98.4 %) and prothrombin time (PT) (pooled SMD = 2.12; 95%CI: 0.44-3.80; I2 = 98.3 %) when compared to paediatric COVID-19 patients. There was no significant difference in terms of features like CRP, procalcitonin, serum albumin, aPTT, mortality and need for mechanical ventilation.
UNASSIGNED: Inflammatory markers like ESR, LDH and PT was significantly higher in influenza patients when compared to COVID-19 in children, while rest of the markers and adverse clinical outcomes were similar between both the groups. Identification of these biomarkers has helped in understanding the distinctness of COVID-19 and influenza virus and develop better management strategies.
UNASSIGNED: Literature search was done in PubMed Central, Scopus, EMBASE, CINAHL, Cochrane library, Google Scholar & ScienceDirect from November 2019 to May 2022. Risk of bias assessment was done through Newcastle Ottawa scale. Meta-analysis was done using random-effects model and the final pooled estimate was reported as pooled odds ratio (OR) or standardized mean difference (SMD) along with 95 % confidence interval (CI) depending on the type of outcome.
UNASSIGNED: About 16 studies were included with most studies having higher risk of bias. Influenza paediatric patients had significantly higher erythrocyte sedimentation rate (ESR) (pooled SMD = 0.60; 95%CI: 0.30-0.91; I2 = 0 %), lactate dehydrogenase (LDH) (pooled SMD = 2.01; 95%CI: 0.37-3.66; I2 = 98.4 %) and prothrombin time (PT) (pooled SMD = 2.12; 95%CI: 0.44-3.80; I2 = 98.3 %) when compared to paediatric COVID-19 patients. There was no significant difference in terms of features like CRP, procalcitonin, serum albumin, aPTT, mortality and need for mechanical ventilation.
UNASSIGNED: Inflammatory markers like ESR, LDH and PT was significantly higher in influenza patients when compared to COVID-19 in children, while rest of the markers and adverse clinical outcomes were similar between both the groups. Identification of these biomarkers has helped in understanding the distinctness of COVID-19 and influenza virus and develop better management strategies.
摘要：
■流感和COVID-19患者在成年人中具有相似的特征和结果。然而,这些疾病之间的差异在儿科年龄组中没有探索，特别是在炎症标志物方面，凝血曲线和结果。因此，我们做了这篇综述来比较炎症，流感和COVID-19感染儿童之间的凝血特征和结果。
■文献检索是在PubMedCentral进行的，Scopus,EMBASE,CINAHL,科克伦图书馆,GoogleScholar&ScienceDirect从2019年11月到2022年5月。通过纽卡斯尔渥太华量表进行偏见风险评估。使用随机效应模型进行荟萃分析，最终汇总估计值报告为汇总比值比（OR）或标准化平均差（SMD）以及95％置信区间（CI），具体取决于结局类型。
■纳入约16项研究，大多数研究偏倚风险较高。流感儿科患者的红细胞沉降率（ESR）明显较高（合并SMD=0.60;95CI：0.30-0.91;I2=0％），与儿科COVID-19患者相比,乳酸脱氢酶(LDH)(合并SMD=2.01;95CI:0.37-3.66;I2=98.4%)和凝血酶原时间(PT)(合并SMD=2.12;95CI:0.44-3.80;I2=98.3%).在CRP等特征方面没有显着差异，降钙素原,血清白蛋白,aPTT,死亡率和机械通气的需要。
■炎症标志物，如ESR，与儿童COVID-19相比，流感患者的LDH和PT明显更高，而两组的其他标志物和不良临床结局相似.这些生物标志物的鉴定有助于理解COVID-19和流感病毒的独特性，并制定更好的管理策略。
■文献检索是在PubMedCentral进行的，Scopus,EMBASE,CINAHL,科克伦图书馆,GoogleScholar&ScienceDirect从2019年11月到2022年5月。通过纽卡斯尔渥太华量表进行偏见风险评估。使用随机效应模型进行荟萃分析，最终汇总估计值报告为汇总比值比（OR）或标准化平均差（SMD）以及95％置信区间（CI），具体取决于结局类型。
■纳入约16项研究，大多数研究偏倚风险较高。流感儿科患者的红细胞沉降率（ESR）明显较高（合并SMD=0.60;95CI：0.30-0.91;I2=0％），与儿科COVID-19患者相比,乳酸脱氢酶(LDH)(合并SMD=2.01;95CI:0.37-3.66;I2=98.4%)和凝血酶原时间(PT)(合并SMD=2.12;95CI:0.44-3.80;I2=98.3%).在CRP等特征方面没有显着差异，降钙素原,血清白蛋白,aPTT,死亡率和机械通气的需要。
■炎症标志物，如ESR，与儿童COVID-19相比，流感患者的LDH和PT明显更高，而两组的其他标志物和不良临床结局相似.这些生物标志物的鉴定有助于理解COVID-19和流感病毒的独特性，并制定更好的管理策略。
