PDF(Pubmed)
Abstract：
Neuroleptic malignant syndrome is characterized by muscle stiffness, hyperthermia, autonomic dysfunction, elevation in serum creatine phosphokinase, and changes in consciousness, which usually occur due to the side effects of life-threatening neuroleptic and antipsychotic drugs, and it can cause high mortality. A few cases of neuroleptic malignant syndrome associated with coronavirus disease 2019 infection and vaccination have been reported in the literature. Our case presented with epileptic seizure and neuroleptic malignant syndrome signs 10 days after receiving a single dose of the BNT162b2 vaccine when under low-dose olanzapine treatment with a diagnosis of autism and epilepsy. According to the laboratory test, the creatine kinase value was very high, there was hyponatremia, and the iron value was low. The patient died. Our aim in reporting this case is to draw attention to the possibility that coronavirus disease 2019 vaccines may trigger neuroleptic malignant syndrome, which can be a fatal complication in patients taking antipsychotics, albeit very rare among the large vaccinated population.
摘要：
抗精神病药恶性综合征的特征是肌肉僵硬，热疗,自主神经功能障碍,血清肌酸磷酸激酶升高，和意识的变化，这通常是由于危及生命的抗精神病药物和抗精神病药物的副作用而发生的，会导致高死亡率.文献中已报道了一些与冠状病毒病2019感染和疫苗接种相关的抗精神病药恶性综合征病例。在接受低剂量奥氮平治疗并诊断为自闭症和癫痫时，我们的病例在接受单剂量BNT162b2疫苗10天后出现癫痫发作和抗精神病药恶性综合征症状。根据实验室测试,肌酸激酶值很高,有低钠血症,铁的价值很低。病人死了。我们报告这种情况的目的是提请注意冠状病毒病2019疫苗可能引发精神安定药恶性综合征的可能性，这可能是服用抗精神病药物的患者的致命并发症，尽管在大量接种疫苗的人群中非常罕见。
