PDF(Pubmed)
Abstract：
UNASSIGNED: Viral infection is responsible for the majority of respiratory tract infections (RTI). This retrospective study evaluates the advantages of using the multiplex Xpert Xpress CoV-2/Flu/RSV plus kit in laboratory diagnosis of RTI caused by the most related viruses.
UNASSIGNED: Data were obtained from medical records between November 2021 and May 2023 for any sample tested using either the Xpert Xpress Flu/RSV kit, Xpert Xpress Flu kit, Xpert Xpress SARS-CoV-2 kit, and Xpert Xpress CoV-2/Flu/RSV plus kit.
UNASSIGNED: Influenza virus A was detected in 8.5% (55/649) of the samples using the Flu PCR kit and in 4.9% (123/2538) using CoV-2/Flu/RSV plus kit, while influenza virus B detection rates were 3.7% (24/649) using the Flu PCR kit and 1.7% (43/2538) using the CoV-2/Flu/RSV plus kit. However, the detection rates using the two kits were comparable when evaluated for the same time period of the year. SARS-CoV-2 infections were detected in 16.9% (1545/9153) and 10.5% (266/2538) of the cases using the SARS-CoV-2 kit and CoV-2/Flu/RSV plus kits, respectively. Respiratory syncytial virus (RSV) was identified in 17.7% (66/372) of children using Flu/RSV kit; this number dropped significantly when age-targeted testing of RSV was performed due to involvements of adults. With the CoV-2/Flu/RSV plus kit, about 34% (35/103) of RSV infections detected were in patients aged >20 years; these cases would have previously been overlooked because adults are not routinely tested for RSV using the Flu/RSV kit. All coinfection cases (n = 16) were only detected with the CoV-2/Flu/RSV plus kit.
UNASSIGNED: The use of Xpert Xpress CoV-2/Flu/RSV plus kit not only results in shorter turnaround times through accurate detection of all four viruses, but also provides information on RSV infection in adults and coinfection rates.
UNASSIGNED: Data were obtained from medical records between November 2021 and May 2023 for any sample tested using either the Xpert Xpress Flu/RSV kit, Xpert Xpress Flu kit, Xpert Xpress SARS-CoV-2 kit, and Xpert Xpress CoV-2/Flu/RSV plus kit.
UNASSIGNED: Influenza virus A was detected in 8.5% (55/649) of the samples using the Flu PCR kit and in 4.9% (123/2538) using CoV-2/Flu/RSV plus kit, while influenza virus B detection rates were 3.7% (24/649) using the Flu PCR kit and 1.7% (43/2538) using the CoV-2/Flu/RSV plus kit. However, the detection rates using the two kits were comparable when evaluated for the same time period of the year. SARS-CoV-2 infections were detected in 16.9% (1545/9153) and 10.5% (266/2538) of the cases using the SARS-CoV-2 kit and CoV-2/Flu/RSV plus kits, respectively. Respiratory syncytial virus (RSV) was identified in 17.7% (66/372) of children using Flu/RSV kit; this number dropped significantly when age-targeted testing of RSV was performed due to involvements of adults. With the CoV-2/Flu/RSV plus kit, about 34% (35/103) of RSV infections detected were in patients aged >20 years; these cases would have previously been overlooked because adults are not routinely tested for RSV using the Flu/RSV kit. All coinfection cases (n = 16) were only detected with the CoV-2/Flu/RSV plus kit.
UNASSIGNED: The use of Xpert Xpress CoV-2/Flu/RSV plus kit not only results in shorter turnaround times through accurate detection of all four viruses, but also provides information on RSV infection in adults and coinfection rates.
摘要：
■病毒感染是大多数呼吸道感染（RTI）的原因。这项回顾性研究评估了使用多重XpertXpressCoV-2/Flu/RSVplus试剂盒在实验室诊断由最相关病毒引起的RTI中的优势。
■数据来自2021年11月至2023年5月之间使用XpertXpress流感/RSV试剂盒测试的任何样本的医疗记录，XpertXpress流感套件，XpertXpressSARS-CoV-2套件，和XpertXpressCoV-2/流感/RSVplus套件。
■使用FluPCR试剂盒在8.5％（55/649）的样品中检测到甲型流感病毒，使用CoV-2/Flu/RSVplus试剂盒在4.9％（123/2538）的样品中检测到甲型流感病毒，而使用FluPCR试剂盒的B型流感病毒检出率为3.7%(24/649)，使用CoV-2/Flu/RSVplus试剂盒的检出率为1.7%(43/2538)。然而,在一年中的同一时间段进行评估时,两种试剂盒的检出率具有可比性.使用SARS-CoV-2试剂盒和CoV-2/Flu/RSVplus试剂盒，在16.9％（1545/9153）和10.5％（266/2538）的病例中检测到SARS-CoV-2感染，分别。使用Flu/RSV试剂盒在17.7％（66/372）的儿童中鉴定出呼吸道合胞病毒（RSV）；由于成年人的参与，当进行针对年龄的RSV测试时，这一数字显着下降。使用CoV-2/流感/RSVplus套件，约34%(35/103)的RSV感染发生在年龄>20岁的患者中;这些病例以前会被忽视,因为成年人没有使用Flu/RSV试剂盒进行RSV常规检测.所有合并感染病例（n=16）仅用CoV-2/Flu/RSVplus试剂盒检测到。
■使用XpertXpressCoV-2/Flu/RSVplus试剂盒不仅通过准确检测所有四种病毒而缩短了周转时间，还提供了有关成人RSV感染和合并感染率的信息。
■数据来自2021年11月至2023年5月之间使用XpertXpress流感/RSV试剂盒测试的任何样本的医疗记录，XpertXpress流感套件，XpertXpressSARS-CoV-2套件，和XpertXpressCoV-2/流感/RSVplus套件。
■使用FluPCR试剂盒在8.5％（55/649）的样品中检测到甲型流感病毒，使用CoV-2/Flu/RSVplus试剂盒在4.9％（123/2538）的样品中检测到甲型流感病毒，而使用FluPCR试剂盒的B型流感病毒检出率为3.7%(24/649)，使用CoV-2/Flu/RSVplus试剂盒的检出率为1.7%(43/2538)。然而,在一年中的同一时间段进行评估时,两种试剂盒的检出率具有可比性.使用SARS-CoV-2试剂盒和CoV-2/Flu/RSVplus试剂盒，在16.9％（1545/9153）和10.5％（266/2538）的病例中检测到SARS-CoV-2感染，分别。使用Flu/RSV试剂盒在17.7％（66/372）的儿童中鉴定出呼吸道合胞病毒（RSV）；由于成年人的参与，当进行针对年龄的RSV测试时，这一数字显着下降。使用CoV-2/流感/RSVplus套件，约34%(35/103)的RSV感染发生在年龄>20岁的患者中;这些病例以前会被忽视,因为成年人没有使用Flu/RSV试剂盒进行RSV常规检测.所有合并感染病例（n=16）仅用CoV-2/Flu/RSVplus试剂盒检测到。
■使用XpertXpressCoV-2/Flu/RSVplus试剂盒不仅通过准确检测所有四种病毒而缩短了周转时间，还提供了有关成人RSV感染和合并感染率的信息。
