Abstract：
OBJECTIVE: Due to the popularity and increasing launch of toothpastes with whitening and sensitivity properties on the market, this study aimed to evaluate the fluoride concentrations in these products, since the concentrations of fluoride directly interfere with the anti-caries potential.
METHODS: This is an experimental, in vitro study, where 37 samples from different batches (n = 3) purchased in different countries, were analysed in duplicate, via the ion-selective electrode technique to verify the concentration (μg/g or ppm F-) of total fluoride (TF), total soluble fluoride (TSF) and ionic fluoride (IF). For a comparative data analysis, ANOVA was applied followed by a Tukey\'s test for multiple comparisons. The level of confidence adopted was 95%.
RESULTS: In the 37 assessed toothpastes, 45.9% contained NaF and 54.1% sodium monofluorophosphate (MFP). The TF found in the formulations ranged from 902.8 to 1539.4 ppm of F (mean: 1165.2 ± 179.3); fluoride concentration in the TSF fraction ranged from 708.8 to 1306.7 ppm of F (mean: 959.5 ± 162.4); IF results ranged from 101.9 to 1162.3 ppm of F (642.2 ± 294.1). Significant differences (p < 0.05) were found in the concentrations of the 59.5% assessed toothpastes in comparisons between declared and measured total fluoride (TF) concentrations, as well as in 62.2% when total fluoride (TF) and total soluble fluoride (TSF) were compared.
CONCLUSIONS: In this study, most of the samples evaluated showed discrepancies when compared to the information declared by the manufacturers. In addition, the soluble concentrations found in half of the samples were lower than total concentrations and this may affect anti-caries effectiveness.
METHODS: This is an experimental, in vitro study, where 37 samples from different batches (n = 3) purchased in different countries, were analysed in duplicate, via the ion-selective electrode technique to verify the concentration (μg/g or ppm F-) of total fluoride (TF), total soluble fluoride (TSF) and ionic fluoride (IF). For a comparative data analysis, ANOVA was applied followed by a Tukey\'s test for multiple comparisons. The level of confidence adopted was 95%.
RESULTS: In the 37 assessed toothpastes, 45.9% contained NaF and 54.1% sodium monofluorophosphate (MFP). The TF found in the formulations ranged from 902.8 to 1539.4 ppm of F (mean: 1165.2 ± 179.3); fluoride concentration in the TSF fraction ranged from 708.8 to 1306.7 ppm of F (mean: 959.5 ± 162.4); IF results ranged from 101.9 to 1162.3 ppm of F (642.2 ± 294.1). Significant differences (p < 0.05) were found in the concentrations of the 59.5% assessed toothpastes in comparisons between declared and measured total fluoride (TF) concentrations, as well as in 62.2% when total fluoride (TF) and total soluble fluoride (TSF) were compared.
CONCLUSIONS: In this study, most of the samples evaluated showed discrepancies when compared to the information declared by the manufacturers. In addition, the soluble concentrations found in half of the samples were lower than total concentrations and this may affect anti-caries effectiveness.
摘要：
目的：由于市场上具有美白和敏感特性的牙膏的普及和越来越多的推出，这项研究旨在评估这些产品中的氟化物浓度，因为氟化物的浓度直接干扰防龋的潜力。
方法：这是一个实验，体外研究，其中在不同国家购买了来自不同批次（n=3）的37个样品，进行了一式两份的分析，通过离子选择电极技术验证总氟化物（TF）的浓度（μg/g或ppmF-），总可溶性氟化物(TSF)和离子氟化物(IF)。为了进行比较数据分析，应用方差分析，然后进行Tukey检验进行多重比较。采用的置信水平为95％。
结果：在37种评估的牙膏中，45.9%含有NaF和54.1%单氟磷酸钠(MFP)。在制剂中发现的TF范围为902.8至1539.4ppm的F(平均值:1165.2±179.3);TSF部分中的氟化物浓度范围为708.8至1306.7ppm的F(平均值:959.5±162.4);IF结果范围为101.9至1162.3ppm的F(642.2±294.1)。在声明和测量的总氟化物（TF）浓度之间的比较中，59.5％评估牙膏的浓度存在显着差异（p<0.05）。当比较总氟化物（TF）和总可溶性氟化物（TSF）时，也为62.2％。
结论：在这项研究中，与制造商声明的信息相比，大多数评估的样品都显示出差异。此外,一半样品中的可溶性浓度低于总浓度，这可能会影响防龋效果。
方法：这是一个实验，体外研究，其中在不同国家购买了来自不同批次（n=3）的37个样品，进行了一式两份的分析，通过离子选择电极技术验证总氟化物（TF）的浓度（μg/g或ppmF-），总可溶性氟化物(TSF)和离子氟化物(IF)。为了进行比较数据分析，应用方差分析，然后进行Tukey检验进行多重比较。采用的置信水平为95％。
结果：在37种评估的牙膏中，45.9%含有NaF和54.1%单氟磷酸钠(MFP)。在制剂中发现的TF范围为902.8至1539.4ppm的F(平均值:1165.2±179.3);TSF部分中的氟化物浓度范围为708.8至1306.7ppm的F(平均值:959.5±162.4);IF结果范围为101.9至1162.3ppm的F(642.2±294.1)。在声明和测量的总氟化物（TF）浓度之间的比较中，59.5％评估牙膏的浓度存在显着差异（p<0.05）。当比较总氟化物（TF）和总可溶性氟化物（TSF）时，也为62.2％。
结论：在这项研究中，与制造商声明的信息相比，大多数评估的样品都显示出差异。此外,一半样品中的可溶性浓度低于总浓度，这可能会影响防龋效果。
