Abstract：
Due to weather and working/operational conditions, plastic degradation produces toxic and non-biodegradable nano and microplastics (N/M-Ps, ranging from 10 nm to 5 mm), and over time these N/M-Ps have integrated with the human cycle through ingestion and inhalation. These N/M-Ps, as serious emerging pollutants, are causing considerable adverse health issues due to up-taken by the cells, tissue, and organs, including the brain. It has been proven that N/M-Ps can cross the blood-brain barrier (via olfactory and blood vessels) and affect the secretion of neuroinflammatory (cytokine and chemokine), transporters, and receptor markers. Neurotoxicity, neuroinflammation, and brain injury, which may result in such scenarios are a serious concern and may cause brain disorders. However, the related pathways and pathogenesis are not well-explored but are the focus of upcoming emerging research. Therefore, as a focus of this editorial, well-organized multidisciplinary research is required to explore associated pathways and pathogenesis, leading to brain mapping and nano-enabled therapeutics in acute and chronic N/M - Ps exposure.
摘要：
由于天气和工作/操作条件，塑料降解产生有毒和不可生物降解的纳米和微米塑料(N/M-Ps，范围从10nm到5mm)，随着时间的推移，这些N/M-P通过摄入和吸入与人的周期整合。这些N/M-PS，作为严重的新兴污染物，由于被细胞摄取而导致相当大的不良健康问题，组织,和器官，包括大脑。已经证明N/M-Ps可以穿过血脑屏障（通过嗅觉和血管）并影响神经炎症（细胞因子和趋化因子）的分泌，运输商,和受体标记。神经毒性，神经炎症，和脑损伤,这可能导致这种情况是一个严重的问题，并可能导致脑部疾病。然而,相关的通路和发病机制尚未得到很好的探索,但却是即将出现的新兴研究的焦点.因此,作为这篇社论的重点，需要组织良好的多学科研究来探索相关的途径和发病机理，在急性和慢性N/M-P暴露中导致大脑映射和纳米功能疗法。
