Abstract：
OBJECTIVE: To determine the accuracy of salivary active matrix metalloproteinase (aMMP)-8 point-of-care test (POCT) for detecting periodontitis in adults, through meta-analysis.
METHODS: Diagnostic studies evaluating the accuracy of salivary/oral rinse aMMP-8 POCT for detecting periodontitis in adults, when compared with clinical examination, were considered eligible. A comprehensive search was performed up to 31 August 2023 through five databases. Quality Assessment of Diagnostic Accuracy Studies 2 was utilized to evaluate the methodological quality of the included articles. Meta-analysis was performed using Bayesian bivariate hierarchical model and subgroup analysis.
RESULTS: From 368 screened studies, 6 studies (4 cross-sectional and 2 longitudinal studies) were included in the meta-analysis. Overall, the pooled sensitivity and specificity of salivary aMMP-8-POCT for detecting periodontitis were 0.63 (95% CI: 0.41-0.82) and 0.84 (95% CI: 0.65-0.95), respectively. Subgroup analyses revealed that the 95% CI for oral fluid types, predefined diagnostic thresholds and the POCT systems largely overlapped, indicating that the differences between them may not be significant.
CONCLUSIONS: Salivary aMMP-8 POCT shows fair accuracy for detecting periodontitis. The diagnostic accuracy cannot be significantly influenced by the types of oral fluids, predefined diagnostic thresholds or the specific POCT systems used. More research is needed to confirm the clinical utility and implementation of aMMP-8 POCT in the diagnosis of periodontitis.
METHODS: Diagnostic studies evaluating the accuracy of salivary/oral rinse aMMP-8 POCT for detecting periodontitis in adults, when compared with clinical examination, were considered eligible. A comprehensive search was performed up to 31 August 2023 through five databases. Quality Assessment of Diagnostic Accuracy Studies 2 was utilized to evaluate the methodological quality of the included articles. Meta-analysis was performed using Bayesian bivariate hierarchical model and subgroup analysis.
RESULTS: From 368 screened studies, 6 studies (4 cross-sectional and 2 longitudinal studies) were included in the meta-analysis. Overall, the pooled sensitivity and specificity of salivary aMMP-8-POCT for detecting periodontitis were 0.63 (95% CI: 0.41-0.82) and 0.84 (95% CI: 0.65-0.95), respectively. Subgroup analyses revealed that the 95% CI for oral fluid types, predefined diagnostic thresholds and the POCT systems largely overlapped, indicating that the differences between them may not be significant.
CONCLUSIONS: Salivary aMMP-8 POCT shows fair accuracy for detecting periodontitis. The diagnostic accuracy cannot be significantly influenced by the types of oral fluids, predefined diagnostic thresholds or the specific POCT systems used. More research is needed to confirm the clinical utility and implementation of aMMP-8 POCT in the diagnosis of periodontitis.
摘要：
目的：确定唾液活性基质金属蛋白酶（aMMP）-8点护理试验（POCT）检测成人牙周炎的准确性，通过荟萃分析。
方法：诊断研究评估唾液/口腔冲洗aMMP-8POCT检测成人牙周炎的准确性，与临床检查相比，被认为是合格的。截至2023年8月31日，通过五个数据库进行了全面搜索。诊断准确性研究2的质量评估用于评估所包括文章的方法学质量。采用贝叶斯双变量分层模型和亚组分析进行Meta分析。
结果：来自368项筛选研究，6项研究（4项横断面研究和2项纵向研究）纳入荟萃分析。总的来说,唾液aMMP-8-POCT检测牙周炎的敏感性和特异性分别为0.63(95%CI:0.41-0.82)和0.84(95%CI:0.65-0.95),分别。亚组分析显示，口腔液类型的95%CI，预定义的诊断阈值和POCT系统大部分重叠，这表明它们之间的差异可能并不显著。
结论：唾液aMMP-8POCT对牙周炎的检测具有相当的准确性。诊断准确性不会受到口腔液体类型的显著影响，预定义的诊断阈值或使用的特定POCT系统。需要更多的研究来证实aMMP-8POCT在牙周炎诊断中的临床实用性和实施。
方法：诊断研究评估唾液/口腔冲洗aMMP-8POCT检测成人牙周炎的准确性，与临床检查相比，被认为是合格的。截至2023年8月31日，通过五个数据库进行了全面搜索。诊断准确性研究2的质量评估用于评估所包括文章的方法学质量。采用贝叶斯双变量分层模型和亚组分析进行Meta分析。
结果：来自368项筛选研究，6项研究（4项横断面研究和2项纵向研究）纳入荟萃分析。总的来说,唾液aMMP-8-POCT检测牙周炎的敏感性和特异性分别为0.63(95%CI:0.41-0.82)和0.84(95%CI:0.65-0.95),分别。亚组分析显示，口腔液类型的95%CI，预定义的诊断阈值和POCT系统大部分重叠，这表明它们之间的差异可能并不显著。
结论：唾液aMMP-8POCT对牙周炎的检测具有相当的准确性。诊断准确性不会受到口腔液体类型的显著影响，预定义的诊断阈值或使用的特定POCT系统。需要更多的研究来证实aMMP-8POCT在牙周炎诊断中的临床实用性和实施。
