Abstract：
Colonoscopy is the gold standard for detecting and resecting adenomas or early stage cancers to reduce the incidence and mortality rates of colorectal cancer. In a recent observational study, texture and color enhancement imaging (TXI) was reported to improve polyp detection during colonoscopy. This randomized controlled trial involving six Japanese institutions aims to confirm the superiority of TXI over standard white-light imaging (WLI) in detecting colorectal lesions during colonoscopy. During the 1-year study period, 960 patients will be enrolled, with 480 patients in the TXI and WLI groups. The primary endpoint is the mean number of adenomas detected per procedure. The secondary endpoints include adenoma detection rate, advanced adenoma detection rate, polyp detection rate, flat polyp detection rate, depressed lesion detection rate, mean polyps detected per procedure, sessile serrated lesion (SSL) detection rate, mean SSLs detected per procedure and adverse events.
摘要：
结肠镜检查是检测和切除腺瘤或早期癌症以降低结直肠癌发病率和死亡率的金标准。在最近的一项观察研究中，据报道,纹理和彩色增强成像(TXI)可改善结肠镜检查期间的息肉检测.这项涉及六个日本机构的随机对照试验旨在证实TXI在结肠镜检查期间检测结直肠病变方面优于标准白光成像（WLI）。在为期一年的研究期间，将招募960名患者，TXI和WLI组480例患者。主要终点是每个程序检测到的腺瘤的平均数量。次要终点包括腺瘤检出率，晚期腺瘤检出率,息肉检出率,扁平息肉检出率，抑郁病变检出率，每次手术检测到的平均息肉，无柄锯齿状病变(SSL)检出率,每个程序检测到的平均SSLs和不良事件。
