Abstract：
The COVID-19 pandemic, with its far-reaching influence on daily life, constituted a highly stressful experience for many people worldwide, jeopardizing individuals\' mental health, particularly in vulnerable populations such as pregnant women. While a growing body of evidence links prenatal maternal stress to biological and developmental alterations in offspring, the specific impact of prenatal exposure to maternal pandemic-related stress (PRS) on infant development remains unclear. A comprehensive literature search was performed in October 2023 according to the PRISMA guidelines, which yielded a total of 28 records. The selected papers investigated a vast range of developmental and biological outcomes in the offspring with large methodological variations. The reviewed studies showed mixed results. Either direct associations between maternal PRS during pregnancy and infant temperament and socio-emotional development, or indirect links, mediated by maternal mental health, emerged in most studies. Furthermore, maternal PRS was associated with epigenetic and brain alterations in the offspring, although studies were limited in number. Collectively, the reviewed findings contribute to a deeper understanding of the role of early adverse exposures on infant development.
摘要：
COVID-19大流行，它对日常生活产生了深远的影响，对全世界许多人来说构成了高度紧张的经历，危害个人心理健康，特别是在孕妇等弱势群体中。虽然越来越多的证据表明产前母体压力与后代的生物学和发育改变有关，产前暴露于孕产妇大流行相关应激(PRS)对婴儿发育的具体影响尚不清楚.根据PRISMA指南，2023年10月进行了全面的文献检索，总共产生了28条记录。选定的论文调查了后代的大量发育和生物学结果，方法上存在很大差异。怀孕期间母亲PRS与婴儿气质和社会情绪发展之间的直接关联，或间接链接，以母亲心理健康为媒介，出现在大多数综述的研究中。此外，母体PRS与后代的表观遗传和大脑改变有关，尽管研究数量有限。总的来说，回顾的发现有助于更深入地了解早期不良暴露对婴儿发育的作用.
