Abstract：
OBJECTIVE: Air quality has been shown to impact the rates of fungal infection of the airway, causing diseases such as acute invasive fungal rhinosinusitis (AIFRS), particularly in immunocompromised patients. We theorize that patients with hematologic malignancies in units with aging air handling units (AHUs) have a higher attack rate of AIFRS.
METHODS: Retrospective chart review identified patients with hematologic malignancy and AIFRS in two distinct and equal time periods between 2013 and 2022, representing the presence of aging AHUs and new AHUs, respectively. Cubic feet per minute (CFM) air flows, AIFRS attack rates, and clinical data were compared between the two groups and statistical analyses performed.
RESULTS: The older AHUs produce air flow of 27,610 CFM and the newer AHUs produce air flow of 80,000 CFM. There were 18 patients with air supplied by older AHUs and 7 patients with air supplied by new AHUs who developed AIFRS. There was a significantly higher AIFRS attack rate for patients supplied by the older AHUs compared with patients supplied by newer AHUs (p = 0.033). The patients supplied by the older AHUs tended to be younger. The white blood cell counts, absolute neutrophil counts, and the mean time to diagnosis did not differ between the two groups.
CONCLUSIONS: To our knowledge, this is the first study to examine AIFRS in immunocompromised patients\' inpatient environment. Further research should explore whether higher CFM AHUs can decrease this disease among our most vulnerable patients.
METHODS: 3 Laryngoscope, 2024.
METHODS: Retrospective chart review identified patients with hematologic malignancy and AIFRS in two distinct and equal time periods between 2013 and 2022, representing the presence of aging AHUs and new AHUs, respectively. Cubic feet per minute (CFM) air flows, AIFRS attack rates, and clinical data were compared between the two groups and statistical analyses performed.
RESULTS: The older AHUs produce air flow of 27,610 CFM and the newer AHUs produce air flow of 80,000 CFM. There were 18 patients with air supplied by older AHUs and 7 patients with air supplied by new AHUs who developed AIFRS. There was a significantly higher AIFRS attack rate for patients supplied by the older AHUs compared with patients supplied by newer AHUs (p = 0.033). The patients supplied by the older AHUs tended to be younger. The white blood cell counts, absolute neutrophil counts, and the mean time to diagnosis did not differ between the two groups.
CONCLUSIONS: To our knowledge, this is the first study to examine AIFRS in immunocompromised patients\' inpatient environment. Further research should explore whether higher CFM AHUs can decrease this disease among our most vulnerable patients.
METHODS: 3 Laryngoscope, 2024.
摘要：
目的：空气质量已被证明会影响气道真菌感染率，引起疾病，如急性侵袭性真菌性鼻-鼻窦炎（AIFRS），特别是在免疫功能低下的患者中。我们认为，在空气处理单元（AHU）老化的单位中，血液系统恶性肿瘤患者的AIFRS发病率更高。
方法：回顾性图表回顾在2013年至2022年的两个不同且相等的时间段内确定了血液系统恶性肿瘤和AIFRS的患者，代表存在老化的AHU和新的AHU，分别。立方英尺/分钟(CFM)气流,AIFRS攻击率，比较两组患者的临床资料并进行统计学分析.
结果：较旧的AHU产生27,610CFM的气流，较新的AHU产生80,000CFM的气流。有18名患者由较老的AHU提供空气，有7名患者由开发AIFRS的新AHU提供空气。与较新的AHU提供的患者相比，较旧的AHU提供的患者的AIFRS发作率明显更高（p=0.033）。由年龄较大的AHU提供的患者往往更年轻。白细胞计数,中性粒细胞绝对计数,两组的平均诊断时间没有差异.
结论：据我们所知，这是第一项在免疫功能低下患者住院环境中检查AIFRS的研究。进一步的研究应该探索高CFMAHU是否可以在我们最脆弱的患者中减少这种疾病。
方法：3喉镜，2024.
方法：回顾性图表回顾在2013年至2022年的两个不同且相等的时间段内确定了血液系统恶性肿瘤和AIFRS的患者，代表存在老化的AHU和新的AHU，分别。立方英尺/分钟(CFM)气流,AIFRS攻击率，比较两组患者的临床资料并进行统计学分析.
结果：较旧的AHU产生27,610CFM的气流，较新的AHU产生80,000CFM的气流。有18名患者由较老的AHU提供空气，有7名患者由开发AIFRS的新AHU提供空气。与较新的AHU提供的患者相比，较旧的AHU提供的患者的AIFRS发作率明显更高（p=0.033）。由年龄较大的AHU提供的患者往往更年轻。白细胞计数,中性粒细胞绝对计数,两组的平均诊断时间没有差异.
结论：据我们所知，这是第一项在免疫功能低下患者住院环境中检查AIFRS的研究。进一步的研究应该探索高CFMAHU是否可以在我们最脆弱的患者中减少这种疾病。
方法：3喉镜，2024.
