PDF(Pubmed)
Abstract：
Streptococcus pyogenes (group A Streptococcus, GAS) is a major human pathogen and causes every year over 600 millions upper respiratory tract onfections worldwide. Untreated or repeated infections may lead to post-infectional sequelae such as rheumatic heart disease, a major cause of GAS-mediated mortality. There is no comprehensive, longitudinal analysis of the M type distribution of upper respiratory tract strains isolated in Poland. Single reports describe rather their antibiotic resistance patterns or focus on the invasive isolates. Our goal was to analyse the clonal structure of the upper respiratory tract GAS isolated over multiple years in Poland. Our analysis revealed a clonal structure similar to the ones observed in high-income countries, with M1, M12, M89, M28, and M77 serotypes constituting over 80% of GAS strains. The M77 serotype is a major carrier of erythromycin resistance and is more often correlated with upper respiratory tract infections than other serotypes.
摘要：
化脓性链球菌（A组链球菌，GAS）是一种主要的人类病原体，每年在全球范围内引起超过6亿例上呼吸道感染。未经治疗或反复感染可能导致感染后后遗症，如风湿性心脏病，GAS介导的死亡率的主要原因。没有全面的,波兰分离的上呼吸道菌株M型分布的纵向分析。单个报告描述了它们的抗生素抗性模式或侧重于侵入性分离株。我们的目标是分析波兰多年分离的上呼吸道GAS的克隆结构。我们的分析揭示了与高收入国家相似的克隆结构，M1、M12、M89、M28和M77血清型占GAS菌株的80%以上。M77血清型是红霉素耐药性的主要载体，与其他血清型相比，与上呼吸道感染的相关性更高。
