精氨酸剥夺通过诱导精氨酸 - 半胱氨酸替代来丰富具有半胱氨酸的肺癌蛋白质组。
关键词: aberrant mRNA translation amino acid shortage arginine deprivation chemotherapy cysteine ferroptosis lung cancer substitutants
Mesh : Humans Cysteine / metabolism Lung Neoplasms / genetics metabolism drug therapy pathology Kelch-Like ECH-Associated Protein 1 / metabolism genetics Proteome / metabolism Arginine / metabolism Mutation Argininosuccinate Synthase / metabolism genetics Cisplatin / pharmacology Cell Line, Tumor Proteomics / methods Gene Expression Regulation, Neoplastic Cell Survival / drug effects RNA, Transfer / metabolism genetics
来 源:
DOI:10.1016/j.molcel.2024.04.012
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