Abstract：
Leptospirosis is a neglected bacterial zoonosis that affects a wide range of mammals, with important implications from a One Health perspective. Over the past years feline leptospirosis has gained increased attention in the scientific community. Here we describe a systematic review with meta-analysis that followed the PRISMA guidelines, with an additional PROSPERO registration. The study provides global seropositivity, urinary shedding rates, global serogroup distribution, descriptive data of leptospires that had been isolated from cats and clinical and laboratory features presented by symptomatic cats with acute disease. The search was carried out in six different databases, with the identification of 79 reports describing leptospiral infection in cats. The pooled frequency of seroreactive cats was 11% (95% CI: 9%-13%), with Javanica and Pomona as the most frequent serogroups found. Frequency for urinary shedding was 8% (95% CI: 5%-10%), with L. interrogans identified in most samples. A total of 16 isolates were isolated from cats, with Bataviae as the most frequent serogroup. Twenty symptomatic cats with confirmed leptospiral infection were identified. Anorexia, lethargy, polydipsia, and bleeding disorders were the clinical signs most frequently reported. The results suggest that cats from some locations are exposed to leptospires and may act as urinary shedders of this pathogen, thus indicating a possible role of this species in disease transmission. Clinical data indicates that acute infection is mostly atypical when compared to dogs, and due to difficulties to define an archetypal clinical presentation in cats, feline leptospirosis is likely to be underdiagnosed disease in this species.
摘要：
钩端螺旋体病是一种被忽视的细菌性人畜共患病，影响范围广泛的哺乳动物，从一个健康的角度来看具有重要意义。在过去的几年中，猫钩端螺旋体病在科学界引起了越来越多的关注。在这里，我们描述了遵循PRISMA指南的荟萃分析的系统综述，还有一个额外的PROSPERO注册。该研究提供了全球血清阳性，排尿率，全球血清群分布，从猫中分离出的钩端螺旋体的描述性数据以及有症状的急性疾病猫的临床和实验室特征。搜索是在六个不同的数据库中进行的，有79份报告描述了猫的钩端螺旋体感染。血清反应性猫的合并频率为11％（95％CI：9％-13％），Javanica和Pomona是最常见的血清群。排尿频率为8%(95%CI:5%-10%)，在大多数样本中都发现了L.从猫中分离出16株,Bataviae是最常见的血清群。鉴定出20只确认有钩端螺旋体感染的有症状的猫。厌食症,嗜睡,多饮,出血性疾病是最常见的临床体征.结果表明，来自某些地方的猫暴露于钩端螺旋体，并可能充当该病原体的尿液脱落者，因此表明该物种在疾病传播中的可能作用。临床数据表明，与狗相比，急性感染大多不典型，由于难以定义猫的典型临床表现，猫钩端螺旋体病很可能是该物种的未诊断疾病。
