Abstract：
BACKGROUND: Allergic rhinitis (AR) is a non-infectious chronic inflammation of the nasal mucosa mainly mediated by immunoglobulin E (IgE) in atopic individuals after exposure to allergens. The application of AR guideline-recommended pharmacotherapies can rapidly relieve symptoms of AR but with poor long-term efficacy, and many of these therapies have side effects. Many natural products and their derivatives have shown potential therapeutic effects on AR with fewer side effects.
OBJECTIVE: This review aims to expand understanding of the roles and mechanisms of natural compounds in the treatment of AR and to highlight the importance of utilizing natural products in the treatment of AR.
METHODS: We conducted a systematic literature search using PubMed, Web of Science, Google Scholar, and Clinical Trials. The search was performed using keywords including natural products, natural compounds, bioproducts, plant extracts, naturally derived products, natural resources, allergic rhinitis, hay fever, pollinosis, nasal allergy. Comprehensive research and compilation of existing literature were conducted.
RESULTS: This article provided a comprehensive review of the potential therapeutic effects and mechanisms of natural compounds in the treatment of AR. We emphasized that natural products primarily exert their effects by modulating signalling pathways such as NF-κB, MAPKs, STAT3/ROR-γt/Foxp3, and GATA3/T-bet, thereby inhibiting the activation and expansion of allergic inflammation. We also discussed their toxicity and clinical applications in AR therapy.
CONCLUSIONS: Taken together, natural products exhibit great potential in the treatment of AR. This review is also expected to facilitate the application of natural products as candidates for treating AR. Furthermore, drug discovery based on natural products has a promising prospect in AR treatment.
OBJECTIVE: This review aims to expand understanding of the roles and mechanisms of natural compounds in the treatment of AR and to highlight the importance of utilizing natural products in the treatment of AR.
METHODS: We conducted a systematic literature search using PubMed, Web of Science, Google Scholar, and Clinical Trials. The search was performed using keywords including natural products, natural compounds, bioproducts, plant extracts, naturally derived products, natural resources, allergic rhinitis, hay fever, pollinosis, nasal allergy. Comprehensive research and compilation of existing literature were conducted.
RESULTS: This article provided a comprehensive review of the potential therapeutic effects and mechanisms of natural compounds in the treatment of AR. We emphasized that natural products primarily exert their effects by modulating signalling pathways such as NF-κB, MAPKs, STAT3/ROR-γt/Foxp3, and GATA3/T-bet, thereby inhibiting the activation and expansion of allergic inflammation. We also discussed their toxicity and clinical applications in AR therapy.
CONCLUSIONS: Taken together, natural products exhibit great potential in the treatment of AR. This review is also expected to facilitate the application of natural products as candidates for treating AR. Furthermore, drug discovery based on natural products has a promising prospect in AR treatment.
摘要：
背景：变应性鼻炎（AR）是特应性个体暴露于变应原后主要由免疫球蛋白E（IgE）介导的鼻粘膜非感染性慢性炎症。AR指南推荐的药物治疗可以迅速缓解AR症状，但长期疗效不佳。其中许多疗法都有副作用。许多天然产物及其衍生物对AR显示出潜在的治疗效果，副作用较少。
目的：这篇综述旨在加深对天然化合物在AR治疗中的作用和机制的理解，并强调利用天然产物治疗AR的重要性。
方法：我们使用PubMed进行了系统的文献检索，WebofScience,谷歌学者，和临床试验。使用包括天然产品在内的关键字进行搜索，天然化合物,生物制品,植物提取物,天然衍生产品，自然资源,过敏性鼻炎,花粉热,花粉症,鼻腔过敏.对现有文献进行了综合研究和整理。
结果：本文对天然化合物在治疗AR中的潜在治疗作用和机制进行了全面综述。我们强调，天然产物主要通过调节NF-κB等信号通路发挥其作用。MAPK,STAT3/ROR-γt/Foxp3和GATA3/T-bet，从而抑制过敏性炎症的激活和扩展。我们还讨论了它们在AR治疗中的毒性和临床应用。
结论：综合来看，天然产物在AR的治疗中表现出巨大的潜力。该综述也有望促进天然产物作为治疗AR的候选物的应用。此外，基于天然产物的药物发现在AR治疗中具有广阔的前景。
目的：这篇综述旨在加深对天然化合物在AR治疗中的作用和机制的理解，并强调利用天然产物治疗AR的重要性。
方法：我们使用PubMed进行了系统的文献检索，WebofScience,谷歌学者，和临床试验。使用包括天然产品在内的关键字进行搜索，天然化合物,生物制品,植物提取物,天然衍生产品，自然资源,过敏性鼻炎,花粉热,花粉症,鼻腔过敏.对现有文献进行了综合研究和整理。
结果：本文对天然化合物在治疗AR中的潜在治疗作用和机制进行了全面综述。我们强调，天然产物主要通过调节NF-κB等信号通路发挥其作用。MAPK,STAT3/ROR-γt/Foxp3和GATA3/T-bet，从而抑制过敏性炎症的激活和扩展。我们还讨论了它们在AR治疗中的毒性和临床应用。
结论：综合来看，天然产物在AR的治疗中表现出巨大的潜力。该综述也有望促进天然产物作为治疗AR的候选物的应用。此外，基于天然产物的药物发现在AR治疗中具有广阔的前景。
