Abstract：
OBJECTIVE: This study aimed to clarify the effectiveness of tart cherries on anthropometric, lipid, and glycemic indices. We also aimed to clarify the appropriate dosage for this effect and suggest directions for future studies.
METHODS: PubMed, Scopus, and Web of Science were searched until May 2022. Twelve eligible trials were included. The pooled results were reported as weighted mean differences (WMD) and 95 % confidence intervals (CIs). The Cochrane risk of bias and GRADE tools were used to assess the risk of bias and certainty of the evidence, respectively.
RESULTS: Tart cherry generally showed no significant effects on cardiometabolic risk factors. But subgroup analysis revealed that tart cherry significantly lowered total cholesterol (WMD: -0.33 mmol/l; 95 % CI: -0.55, -0.10), triglyceride (WMD: -0.19 mmol/l; 95 % CI: -0.26, -0.12), and low-density lipoprotein cholesterol (WMD: -0.36 mmol/l; 95 % CI: -0.58, -0.14), in unhealthy populations. Additionally, subgroup analysis indicated that the favorable effects of tart cherry were more pronounced in a single dose, longer duration, elderly, and obese individuals. Dose-response analysis revealed that 20 ml concentrate has the greatest effect in reducing total cholesterol (WMD: -0.40 mmol/l; 95 % CI: -0.61, -0.19), triglyceride (WMD: -0.23 mmol/l; 95 % CI: -0.33, -0.13), and elevating high-density lipoprotein cholesterol (WMD: 0.20 mmol/l; 95 % CI: 0.17, 0.22).
CONCLUSIONS: Tart cherry supplementation did not have significant effects on anthropometric and glycemic indices, but can improve lipid profile, especially in a single dose, longer duration, and in elderly, obese, and unhealthy individuals.
METHODS: PubMed, Scopus, and Web of Science were searched until May 2022. Twelve eligible trials were included. The pooled results were reported as weighted mean differences (WMD) and 95 % confidence intervals (CIs). The Cochrane risk of bias and GRADE tools were used to assess the risk of bias and certainty of the evidence, respectively.
RESULTS: Tart cherry generally showed no significant effects on cardiometabolic risk factors. But subgroup analysis revealed that tart cherry significantly lowered total cholesterol (WMD: -0.33 mmol/l; 95 % CI: -0.55, -0.10), triglyceride (WMD: -0.19 mmol/l; 95 % CI: -0.26, -0.12), and low-density lipoprotein cholesterol (WMD: -0.36 mmol/l; 95 % CI: -0.58, -0.14), in unhealthy populations. Additionally, subgroup analysis indicated that the favorable effects of tart cherry were more pronounced in a single dose, longer duration, elderly, and obese individuals. Dose-response analysis revealed that 20 ml concentrate has the greatest effect in reducing total cholesterol (WMD: -0.40 mmol/l; 95 % CI: -0.61, -0.19), triglyceride (WMD: -0.23 mmol/l; 95 % CI: -0.33, -0.13), and elevating high-density lipoprotein cholesterol (WMD: 0.20 mmol/l; 95 % CI: 0.17, 0.22).
CONCLUSIONS: Tart cherry supplementation did not have significant effects on anthropometric and glycemic indices, but can improve lipid profile, especially in a single dose, longer duration, and in elderly, obese, and unhealthy individuals.
摘要：
目的：本研究旨在阐明酸樱桃对人体测量的有效性，脂质，和血糖指数。我们还旨在阐明这种作用的适当剂量，并为未来的研究提供方向。
方法：PubMed，Scopus,和WebofScience一直搜索到2022年5月。包括12项符合条件的试验。汇总结果报告为加权平均差异（WMD）和95％置信区间（CI）。使用Cochrane偏差风险和GRADE工具来评估偏差风险和证据的确定性，分别。
结果：Tartcherry通常对心脏代谢危险因素没有显着影响。但是亚组分析显示，酸樱桃显着降低总胆固醇（WMD：-0.33mmol/l；95％CI：-0.55，-0.10），甘油三酯（WMD：-0.19mmol/l；95%CI：-0.26，-0.12），和低密度脂蛋白胆固醇（WMD：-0.36mmol/l；95％CI：-0.58，-0.14），在不健康的人群中。此外,亚组分析表明，酸樱桃的有利作用在单剂量更明显，持续时间较长，老年人,和肥胖的人。剂量反应分析表明，20毫升浓缩物在降低总胆固醇方面具有最大的作用（WMD：-0.40mmol/l；95％CI：-0.61，-0.19），甘油三酯（WMD：-0.23mmol/l；95%CI：-0.33，-0.13），并升高高密度脂蛋白胆固醇（WMD：0.20mmol/l；95％CI：0.17，0.22）。
结论：补充Tart樱桃对人体测量和血糖指数没有显著影响，但可以改善血脂状况，尤其是单剂量，持续时间较长，在老年人中，肥胖，不健康的人。
方法：PubMed，Scopus,和WebofScience一直搜索到2022年5月。包括12项符合条件的试验。汇总结果报告为加权平均差异（WMD）和95％置信区间（CI）。使用Cochrane偏差风险和GRADE工具来评估偏差风险和证据的确定性，分别。
结果：Tartcherry通常对心脏代谢危险因素没有显着影响。但是亚组分析显示，酸樱桃显着降低总胆固醇（WMD：-0.33mmol/l；95％CI：-0.55，-0.10），甘油三酯（WMD：-0.19mmol/l；95%CI：-0.26，-0.12），和低密度脂蛋白胆固醇（WMD：-0.36mmol/l；95％CI：-0.58，-0.14），在不健康的人群中。此外,亚组分析表明，酸樱桃的有利作用在单剂量更明显，持续时间较长，老年人,和肥胖的人。剂量反应分析表明，20毫升浓缩物在降低总胆固醇方面具有最大的作用（WMD：-0.40mmol/l；95％CI：-0.61，-0.19），甘油三酯（WMD：-0.23mmol/l；95%CI：-0.33，-0.13），并升高高密度脂蛋白胆固醇（WMD：0.20mmol/l；95％CI：0.17，0.22）。
结论：补充Tart樱桃对人体测量和血糖指数没有显著影响，但可以改善血脂状况，尤其是单剂量，持续时间较长，在老年人中，肥胖，不健康的人。
