Abstract：
UNASSIGNED: Huntington\'s disease (HD) is a neurodegenerative disorder marked by cognitive impairment, movement abnormalities, and behavioral disturbances. The Stroop Color Word Test (SCWT) is a widely used tool to detect cognitive decline in HD. Variations in SCWT formats-horizontal (original) and vertical (Golden)-may influence performance, given HD\'s impact on cognitive and oculomotor abilities.
UNASSIGNED: This study aimed to compare the effectiveness of the horizontal and Golden vertical SCWT formats in detecting cognitive decline in HD, and to determine how performance may have been influenced by eye movement abnormalities.
UNASSIGNED: Forty-five participants with genetically confirmed HD were recruited. Both SCWT formats were administered to each participant in a counterbalanced fashion. Individual performance of all three sections on each format was standardized across 2 different norms. Raw and normed scores on each variation were compared and correlated with eye movement ratings on the Unified Huntington\'s Disease Rating Scale.
UNASSIGNED: The Golden variation elicited significantly slower responses, particularly in the Word Reading section, across two benchmark norms. Statistical analysis revealed significant performance differences between the two formats. Correlations between vertical eye movement ratings and performance on the Golden SCWT were highly significant, highlighting the impact of oculomotor coordination on cognitive assessments in HD.
UNASSIGNED: This study underscores the importance of considering test format in cognitive assessments for HD. The Golden vertical SCWT demonstrates increased sensitivity in detecting deficits in HD, possibly linked to vertical saccade abnormalities. These insights are important for improving the sensitivity of cognitive assessments and monitoring disease progression in HD research and clinical practice.
UNASSIGNED: This study aimed to compare the effectiveness of the horizontal and Golden vertical SCWT formats in detecting cognitive decline in HD, and to determine how performance may have been influenced by eye movement abnormalities.
UNASSIGNED: Forty-five participants with genetically confirmed HD were recruited. Both SCWT formats were administered to each participant in a counterbalanced fashion. Individual performance of all three sections on each format was standardized across 2 different norms. Raw and normed scores on each variation were compared and correlated with eye movement ratings on the Unified Huntington\'s Disease Rating Scale.
UNASSIGNED: The Golden variation elicited significantly slower responses, particularly in the Word Reading section, across two benchmark norms. Statistical analysis revealed significant performance differences between the two formats. Correlations between vertical eye movement ratings and performance on the Golden SCWT were highly significant, highlighting the impact of oculomotor coordination on cognitive assessments in HD.
UNASSIGNED: This study underscores the importance of considering test format in cognitive assessments for HD. The Golden vertical SCWT demonstrates increased sensitivity in detecting deficits in HD, possibly linked to vertical saccade abnormalities. These insights are important for improving the sensitivity of cognitive assessments and monitoring disease progression in HD research and clinical practice.
摘要：
■亨廷顿病（HD）是一种以认知障碍为特征的神经退行性疾病，运动异常，和行为障碍。Stroop颜色词测试（SCWT）是一种广泛使用的工具，用于检测HD的认知能力下降。SCWT格式的变化-水平（原始）和垂直（金色）-可能会影响性能，鉴于HD对认知和动眼能力的影响。
■这项研究旨在比较水平和金色垂直SCWT格式在检测HD认知下降方面的有效性，并确定眼睛运动异常如何影响性能。
■招募了45名遗传证实的HD参与者。两种SCWT格式都以平衡的方式给予每个参与者。每种格式的所有三个部分的个人表现都在2个不同的规范中进行了标准化。在统一亨廷顿疾病评定量表上，对每个变异的原始和标准化评分进行比较，并与眼球运动评分相关。
■黄金变异引起的反应明显较慢，特别是在单词阅读部分，跨越两个基准规范。统计分析显示两种格式之间的显著性能差异。垂直眼动等级与GoldenSCWT性能之间的相关性非常显着，强调动眼协调对HD认知评估的影响。
■这项研究强调了在HD认知评估中考虑测试格式的重要性。金色垂直SCWT在检测HD缺陷方面表现出更高的灵敏度，可能与垂直扫视异常有关.这些见解对于提高认知评估的敏感性和监测HD研究和临床实践中的疾病进展非常重要。
■这项研究旨在比较水平和金色垂直SCWT格式在检测HD认知下降方面的有效性，并确定眼睛运动异常如何影响性能。
■招募了45名遗传证实的HD参与者。两种SCWT格式都以平衡的方式给予每个参与者。每种格式的所有三个部分的个人表现都在2个不同的规范中进行了标准化。在统一亨廷顿疾病评定量表上，对每个变异的原始和标准化评分进行比较，并与眼球运动评分相关。
■黄金变异引起的反应明显较慢，特别是在单词阅读部分，跨越两个基准规范。统计分析显示两种格式之间的显著性能差异。垂直眼动等级与GoldenSCWT性能之间的相关性非常显着，强调动眼协调对HD认知评估的影响。
■这项研究强调了在HD认知评估中考虑测试格式的重要性。金色垂直SCWT在检测HD缺陷方面表现出更高的灵敏度，可能与垂直扫视异常有关.这些见解对于提高认知评估的敏感性和监测HD研究和临床实践中的疾病进展非常重要。
