PDF(Pubmed)
Abstract：
UNASSIGNED: Alzheimer\'s disease (AD) and behavioral variant frontotemporal dementia (bvFTD) show differential vulnerability to large-scale brain functional networks. Plasma neurofilament light (NfL), a promising biomarker of neurodegeneration, has been linked in AD patients to glucose metabolism changes in AD-related regions. However, it is unknown whether plasma NfL would be similarly associated with disease-specific functional connectivity changes in AD and bvFTD.
UNASSIGNED: Our study examined the associations between plasma NfL and functional connectivity of the default mode and salience networks in patients with AD and bvFTD.
UNASSIGNED: Plasma NfL and neuroimaging data from patients with bvFTD (n = 16) and AD or mild cognitive impairment (n = 38; AD + MCI) were analyzed. Seed-based functional connectivity maps of key regions within the default mode and salience networks were obtained and associated with plasma NfL in these patients.
UNASSIGNED: We demonstrated divergent associations between NfL and functional connectivity in AD + MCI and bvFTD patients. Specifically, AD + MCI patients showed lower default mode network functional connectivity with higher plasma NfL, while bvFTD patients showed lower salience network functional connectivity with higher plasma NfL. Further, lower NfL-related default mode network connectivity in AD + MCI patients was associated with lower Montreal Cognitive Assessment scores and higher Clinical Dementia Rating sum-of-boxes scores, although NfL-related salience network connectivity in bvFTD patients was not associated with Neuropsychiatric Inventory Questionnaire scores.
UNASSIGNED: Our findings indicate that plasma NfL is differentially associated with brain functional connectivity changes in AD and bvFTD.
UNASSIGNED: Our study examined the associations between plasma NfL and functional connectivity of the default mode and salience networks in patients with AD and bvFTD.
UNASSIGNED: Plasma NfL and neuroimaging data from patients with bvFTD (n = 16) and AD or mild cognitive impairment (n = 38; AD + MCI) were analyzed. Seed-based functional connectivity maps of key regions within the default mode and salience networks were obtained and associated with plasma NfL in these patients.
UNASSIGNED: We demonstrated divergent associations between NfL and functional connectivity in AD + MCI and bvFTD patients. Specifically, AD + MCI patients showed lower default mode network functional connectivity with higher plasma NfL, while bvFTD patients showed lower salience network functional connectivity with higher plasma NfL. Further, lower NfL-related default mode network connectivity in AD + MCI patients was associated with lower Montreal Cognitive Assessment scores and higher Clinical Dementia Rating sum-of-boxes scores, although NfL-related salience network connectivity in bvFTD patients was not associated with Neuropsychiatric Inventory Questionnaire scores.
UNASSIGNED: Our findings indicate that plasma NfL is differentially associated with brain functional connectivity changes in AD and bvFTD.
摘要：
■阿尔茨海默病（AD）和行为变异额颞叶痴呆（bvFTD）对大规模脑功能网络表现出不同的脆弱性。等离子神经丝光（NfL），一种有希望的神经变性生物标志物，已在AD患者中与AD相关区域的葡萄糖代谢变化有关。然而,目前尚不清楚血浆NfL是否与AD和bvFTD的疾病特异性功能连接变化相关.
■我们的研究检查了AD和bvFTD患者血浆NfL与默认模式和显着性网络的功能连接之间的关联。
■分析了bvFTD（n=16）和AD或轻度认知障碍（n=38；AD+MCI）患者的血浆NfL和神经影像学数据。获得了默认模式和显著性网络内关键区域的基于种子的功能连接图，并与这些患者的血浆NfL相关联。
■我们证明了AD+MCI和bvFTD患者的NfL和功能连接之间的不同关联。具体来说,AD+MCI患者显示出较低的默认模式网络功能连通性，血浆NfL较高，而bvFTD患者显示较低的显著性网络功能连通性，血浆NfL较高。Further,AD+MCI患者较低的NfL相关默认模式网络连接与较低的蒙特利尔认知评估评分和较高的临床痴呆评分框总和评分相关,尽管bvFTD患者的NfL相关显著性网络连接与神经精神调查问卷评分无关.
■我们的发现表明，血浆NfL与AD和bvFTD的脑功能连通性变化差异相关。
■我们的研究检查了AD和bvFTD患者血浆NfL与默认模式和显着性网络的功能连接之间的关联。
■分析了bvFTD（n=16）和AD或轻度认知障碍（n=38；AD+MCI）患者的血浆NfL和神经影像学数据。获得了默认模式和显著性网络内关键区域的基于种子的功能连接图，并与这些患者的血浆NfL相关联。
■我们证明了AD+MCI和bvFTD患者的NfL和功能连接之间的不同关联。具体来说,AD+MCI患者显示出较低的默认模式网络功能连通性，血浆NfL较高，而bvFTD患者显示较低的显著性网络功能连通性，血浆NfL较高。Further,AD+MCI患者较低的NfL相关默认模式网络连接与较低的蒙特利尔认知评估评分和较高的临床痴呆评分框总和评分相关,尽管bvFTD患者的NfL相关显著性网络连接与神经精神调查问卷评分无关.
■我们的发现表明，血浆NfL与AD和bvFTD的脑功能连通性变化差异相关。
