Abstract：
Understanding patient non-adherence to prescribed antibiotics can inform clinical practices, patient counseling, and antibiotic efficacy study design in dermatology. The primary objective was to determine the rate of and reasons for antibiotic non-adherence in the dermatologic surgery setting. The secondary objective was to test the applicability of previously studied survey questions for antibiotic non-adherence screening in the dermatologic surgery setting. Five academic outpatient dermatologic surgery centers across the United States conducted one multicenter prospective cohort study. Dermatologic surgery patients ≥ 18 years of age who were prescribed an antibiotic were included as part of this study. 15.2% (42/276) of patients did not adhere to their antibiotic regimen after dermatologic surgery. Most common reasons for incomplete antibiotic courses included forgotten antibiotics (42.9%,18/42) and side effects (28.6%, 12/42). Previously evaluated questions to identify and predict non-adherence had modest performance in the dermatologic surgery setting (Area under the curve of 0.669 [95% CI (0.583-0.754)]). Antibiotic non-adherence after skin surgery is prevalent and commonly due to reasons that physicians can address with patients.
摘要：
了解患者不遵守处方抗生素可以为临床实践提供信息。病人咨询,和皮肤科抗生素疗效研究设计。主要目的是确定皮肤科手术环境中抗生素不依从性的发生率和原因。次要目标是测试先前研究的调查问题在皮肤科手术环境中用于抗生素不依从性筛查的适用性。美国五个学术门诊皮肤科手术中心进行了一项多中心前瞻性队列研究。接受抗生素治疗的年龄≥18岁的皮肤手术患者被纳入本研究。15.2％（42/276）的患者在皮肤科手术后未遵守抗生素方案。抗生素疗程不全的最常见原因包括忘记抗生素(42.9%，18/42）和副作用（28.6%，12/42).先前评估的识别和预测非依从性的问题在皮肤病学手术环境中表现不大（0.669[95％CI（0.583-0.754）]的曲线下面积）。皮肤手术后抗生素不依从性很普遍，通常是由于医生可以解决患者的原因。
