PDF(Pubmed)
Abstract：
BACKGROUND: The incidence of malignant tumors has increased in patients with non-paraneoplastic pemphigus, although there has been no systematic analysis of global epidemiology.
OBJECTIVE: To explore the epidemiology of various types of non-paraneoplastic pemphigus associated with malignant tumors.
METHODS: Five databases from establishment through October 20, 2023, were searched. STATA SE 17 was used for the data analysis. Subgroup, meta-regression, and sensitivity analyses were used to evaluate the heterogeneity of pooled studies.
RESULTS: A total of 6679 participants were included in our meta-analysis from 16 studies. The aggregated prevalence of tumors in patients diagnosed with pemphigus was 8%. The prevalence was 7% in patients with pemphigus vulgaris, 10% in those with pemphigus foliaceus, and 12% in individuals diagnosed with other types of pemphigus. The prevalence was 8% in Asia, 11% in Europe, and 8% in North America. From a country-specific perspective, patients with pemphigus from Israel, Greece, and Germany exhibited a higher prevalence of tumors at 11%. Furthermore, when categorized by the duration of the study period, the highest prevalence was observed in studies spanning 10 to 20 years, at 11%.
CONCLUSIONS: These findings demonstrate the incidence and prevalence of malignant tumors in patients with non-paraneoplastic pemphigus, which may achieve early detection and intervention, and then reduce mortality rates.
OBJECTIVE: To explore the epidemiology of various types of non-paraneoplastic pemphigus associated with malignant tumors.
METHODS: Five databases from establishment through October 20, 2023, were searched. STATA SE 17 was used for the data analysis. Subgroup, meta-regression, and sensitivity analyses were used to evaluate the heterogeneity of pooled studies.
RESULTS: A total of 6679 participants were included in our meta-analysis from 16 studies. The aggregated prevalence of tumors in patients diagnosed with pemphigus was 8%. The prevalence was 7% in patients with pemphigus vulgaris, 10% in those with pemphigus foliaceus, and 12% in individuals diagnosed with other types of pemphigus. The prevalence was 8% in Asia, 11% in Europe, and 8% in North America. From a country-specific perspective, patients with pemphigus from Israel, Greece, and Germany exhibited a higher prevalence of tumors at 11%. Furthermore, when categorized by the duration of the study period, the highest prevalence was observed in studies spanning 10 to 20 years, at 11%.
CONCLUSIONS: These findings demonstrate the incidence and prevalence of malignant tumors in patients with non-paraneoplastic pemphigus, which may achieve early detection and intervention, and then reduce mortality rates.
摘要：
背景：非副肿瘤性天疱疮患者的恶性肿瘤发病率增加，尽管尚未对全球流行病学进行系统分析。
目的：探讨与恶性肿瘤相关的各类非副肿瘤性天疱疮的流行病学特征。
方法：检索了从建立到2023年10月20日的5个数据库。STATASE17用于数据分析。子组,元回归，和敏感性分析用于评估合并研究的异质性.
结果：我们的荟萃分析中纳入了来自16项研究的6679名参与者。诊断为天疱疮的患者中肿瘤的总患病率为8％。寻常型天疱疮患者的患病率为7％，10%的天疱疮患者，在被诊断为其他类型天疱疮的个体中，占12%。亚洲的患病率为8%，11%在欧洲和8%在北美。从特定国家的角度来看，来自以色列的天疱疮患者，希腊,德国的肿瘤患病率更高，为11%。此外，当按研究期的持续时间分类时，在为期10到20年的研究中观察到最高的患病率，在11%。
结论：这些发现证明了非副肿瘤性天疱疮患者中恶性肿瘤的发生率和患病率。可以实现早期发现和干预，然后降低死亡率。
目的：探讨与恶性肿瘤相关的各类非副肿瘤性天疱疮的流行病学特征。
方法：检索了从建立到2023年10月20日的5个数据库。STATASE17用于数据分析。子组,元回归，和敏感性分析用于评估合并研究的异质性.
结果：我们的荟萃分析中纳入了来自16项研究的6679名参与者。诊断为天疱疮的患者中肿瘤的总患病率为8％。寻常型天疱疮患者的患病率为7％，10%的天疱疮患者，在被诊断为其他类型天疱疮的个体中，占12%。亚洲的患病率为8%，11%在欧洲和8%在北美。从特定国家的角度来看，来自以色列的天疱疮患者，希腊,德国的肿瘤患病率更高，为11%。此外，当按研究期的持续时间分类时，在为期10到20年的研究中观察到最高的患病率，在11%。
结论：这些发现证明了非副肿瘤性天疱疮患者中恶性肿瘤的发生率和患病率。可以实现早期发现和干预，然后降低死亡率。
