%0 Journal Article
%T Epidemiology of malignant tumors in patients with pemphigus: an analysis of trends from 1955 to 2021.
%A Luo Y
%A Fei X
%A Wang M
%A Yang H
%A Zhang Y
%A Chen Y
%A Luo Y
%A Ding X
%A Gao C
%A Shen F
%A Wang R
%A Li B
%A Kuai L
%A Zheng Q
%A Li M
%A Song J
%J Clin Exp Med
%V 24
%N 1
%D 2024 May 17
%M 38758217
%F 5.057
%R 10.1007/s10238-024-01354-8
%X <B>BACKGROUND: </B>The incidence of malignant tumors has increased in patients with non-paraneoplastic pemphigus, although there has been no systematic analysis of global epidemiology.<BR><B>OBJECTIVE: </B>To explore the epidemiology of various types of non-paraneoplastic pemphigus associated with malignant tumors.<BR><B>METHODS: </B>Five databases from establishment through October 20, 2023, were searched. STATA SE 17 was used for the data analysis. Subgroup, meta-regression, and sensitivity analyses were used to evaluate the heterogeneity of pooled studies.<BR><B>RESULTS: </B>A total of 6679 participants were included in our meta-analysis from 16 studies. The aggregated prevalence of tumors in patients diagnosed with pemphigus was 8%. The prevalence was 7% in patients with pemphigus vulgaris, 10% in those with pemphigus foliaceus, and 12% in individuals diagnosed with other types of pemphigus. The prevalence was 8% in Asia, 11% in Europe, and 8% in North America. From a country-specific perspective, patients with pemphigus from Israel, Greece, and Germany exhibited a higher prevalence of tumors at 11%. Furthermore, when categorized by the duration of the study period, the highest prevalence was observed in studies spanning 10 to 20 years, at 11%.<BR><B>CONCLUSIONS: </B>These findings demonstrate the incidence and prevalence of malignant tumors in patients with non-paraneoplastic pemphigus, which may achieve early detection and intervention, and then reduce mortality rates.