Abstract：
Ferulic acid (FA) is a naturally occurring phenolic compound commonly found in the plant Ferula communis. This study aims to investigate the hepatoprotective effect of FA and its derivatives (methyl ferulic acid and trans-ferulic acid) against oxidative stress and inflammation-related hepatotoxicity due to toxicants based on the results of different non-clinical and preclinical tests. For this, data was collected from different reliable electronic databases such as PubMed, Google Scholar, and ScienceDirect, etc. The results of this investigation demonstrated that FA and its derivatives have potent hepatoprotective effects against oxidative stress and inflammation-related damage. The findings also revealed that these protective effects are due to the antioxidant and anti-inflammatory effects of the chemical compound. FA and its analogues significantly inhibit free radical generation and hinder the effects of proinflammatory markers and inflammatory enzymes, resulting in diminished cytotoxic and apoptotic hepatocyte death. The compounds also prevent intracellular lipid accumulation and provide protective effects.
摘要：
阿魏酸（FA）是一种天然存在的酚类化合物，通常在植物阿魏子中发现。本研究旨在研究FA及其衍生物（甲基阿魏酸和反式阿魏酸）对氧化应激和炎症相关的肝毒性的保护作用，这是基于不同的非临床和临床前试验的结果。为此，数据是从不同的可靠电子数据库收集的，如PubMed，谷歌学者，和科学直接，等。这项研究的结果表明，FA及其衍生物具有有效的抗氧化应激和炎症相关损伤的肝脏保护作用。研究结果还表明，这些保护作用是由于化合物的抗氧化和抗炎作用。FA及其类似物显著抑制自由基生成，阻碍促炎标志物和炎症酶的作用，导致细胞毒性和凋亡性肝细胞死亡减少。所述化合物还防止细胞内脂质积累并提供保护作用。
