Abstract：
Objectives: Several studies have indicated that dietary interventions may offer protection against the development of cardiac damage in the case of anthracycline-induced cardiomyopathy (AIC). The goal of this study was to assess whether an evidence-based cardioprotective diet can be effective in preventing AIC in patients with breast cancer. Design: Randomized, open-label, controlled trial. The study period was set for 18 weeks, and the data were analyzed by generalized estimating equation modeling and one-way repeated measures analysis of variance. Setting/Location: Shahid Rajaie Hospital affiliated (Tehran, Iran). Subjects: Fifty anthracycline-treated patients with breast cancer. Interventions: Patients were randomized to receive either a 2-hour training in evidence-based cardio-protective diet or Carvedilol 6.25 mg bid. Outcome Measures: The primary outcome was the number of patients with abnormal left ventricular ejection fraction (LVEF) after 18 weeks. Results: At week 18, 12 (48%) out of 25 participants in the cardioprotective diet group had abnormal LVEF in comparison with 21 (84%) out of 25 in the carvedilol group (p = 0.007). Also, 2 (8%) out of 25 in the cardioprotective diet group compared with 7 (28%) out of 25 participants in the carvedilol group had abnormal global longitudinal strain (p = 0.066). The diet group showed significant improvements in the quality-of-life dimensions named \"health change\" and \"general health\" compared with the carvedilol group using the Short Form-36 Health Survey questionnaire. Conclusions: This study suggests that an evidence-based cardioprotective diet can contribute to the prevention of AIC. Although current treatments for AIC can be effective, further research is mandatory for more options.
摘要：
目标：一些研究表明，在蒽环类抗生素诱发的心肌病（AIC）的情况下，饮食干预可以防止心脏损害的发展。这项研究的目的是评估基于证据的心脏保护性饮食是否可以有效预防乳腺癌患者的AIC。设计：随机，开放标签，对照试验。研究时间设定为18周，并通过广义估计方程模型和单向重复测量方差分析对数据进行分析。设置/位置：ShahidRajaie医院附属（德黑兰，伊朗)。受试者：50例蒽环类药物治疗的乳腺癌患者。干预措施：患者随机接受2小时的循证心脏保护饮食培训或卡维地洛6.25mgbid。结果测量：主要结果是18周后左心室射血分数（LVEF）异常的患者人数。结果：在第18周，心脏保护性饮食组的25名参与者中有12名（48％）的LVEF异常，而卡维地洛组的25名参与者中有21名（84％）的LVEF异常（p=0.007）。此外，心脏保护性饮食组中25人中有2人（8％）与卡维地洛组25人中有7人（28％）的整体纵向应变异常（p=0.066）。使用简短表格36健康调查问卷，与卡维地洛组相比，饮食组的生活质量维度“健康变化”和“总体健康”显着改善。结论：这项研究表明，基于证据的心脏保护饮食可以有助于预防AIC。虽然目前对AIC的治疗可能是有效的，进一步的研究对于更多的选择是强制性的。
