PDF(Pubmed)
Abstract：
UNASSIGNED: Chronic liver disease is a common and important clinical problem.Hepatorenal syndrome (HRS) is a life threatening complication. Serum creatinine (Cr) remains the only conventional indicator of renal function. However, the interpretation of serum Cr level can be confounded by malnutrition and reduced muscle mass often observed in patients with severe liver disease. Here, we present a cross-sectional study to explore the sensitivity and specificity of other markers as urinary KIM-1 and NGAL for cases of HRS.
UNASSIGNED: Cross-sectional study was conducted on 88 patients who were admitted to Alexandria main university hospital. Enrolled patients were divided in two groups; group 1: patients with advanced liver cirrhosis (child B and C) who have normal kidney functions while group 2: patients who developed HRS. Stata© version 14.2 software package was used for analysis.
UNASSIGNED: Group 1 included 18 males and 26 females compared to 25 males and 19 females in group 2 (p = 0.135). Only the urinary KIM-1 showed a statistically significant difference between both groups in the multivariate logistic regression analysis adjusted for gender, serum bilirubin, serum albumin, INR, serum K, AST and ALT levels.
UNASSIGNED: In conclusion, our study aligns with prior research, as seen in the consistent findings regarding Urinary NGAL elevation in cirrhotic patients with AKI. Urinary KIM-1, independent of Urinary NGAL, may have a role in precisely distinguishing between advanced liver cirrhosis and HRS and merits further exploration.
UNASSIGNED: Cross-sectional study was conducted on 88 patients who were admitted to Alexandria main university hospital. Enrolled patients were divided in two groups; group 1: patients with advanced liver cirrhosis (child B and C) who have normal kidney functions while group 2: patients who developed HRS. Stata© version 14.2 software package was used for analysis.
UNASSIGNED: Group 1 included 18 males and 26 females compared to 25 males and 19 females in group 2 (p = 0.135). Only the urinary KIM-1 showed a statistically significant difference between both groups in the multivariate logistic regression analysis adjusted for gender, serum bilirubin, serum albumin, INR, serum K, AST and ALT levels.
UNASSIGNED: In conclusion, our study aligns with prior research, as seen in the consistent findings regarding Urinary NGAL elevation in cirrhotic patients with AKI. Urinary KIM-1, independent of Urinary NGAL, may have a role in precisely distinguishing between advanced liver cirrhosis and HRS and merits further exploration.
摘要：
■慢性肝病是一个常见而重要的临床问题。肝肾综合征(HRS)是一种危及生命的并发症。血清肌酐（Cr）仍然是肾功能的唯一常规指标。然而,血清Cr水平的解释可能与严重肝病患者经常观察到的营养不良和肌肉质量减少有关。这里,我们进行了一项横断面研究,探讨尿KIM-1和NGAL等其他标志物对HRS的敏感性和特异性.
■对亚历山大大学主要医院收治的88名患者进行了横断面研究。注册患者分为两组；第1组：肾功能正常的晚期肝硬化患者（儿童B和C），而第2组：发生HRS的患者。Stata©14.2版软件包用于分析。
■第1组包括18名男性和26名女性，而第2组包括25名男性和19名女性（p=0.135）。在校正性别的多变量logistic回归分析中，只有尿KIM-1在两组之间显示出统计学上的显著差异，血清胆红素，血清白蛋白,INR,血清K,AST和ALT水平。
■总而言之，我们的研究与先前的研究一致，如关于肝硬化AKI患者尿NGAL升高的一致发现所示。尿KIM-1，独立于尿NGAL，可能在精确区分晚期肝硬化和HRS中起作用，值得进一步探索。
■对亚历山大大学主要医院收治的88名患者进行了横断面研究。注册患者分为两组；第1组：肾功能正常的晚期肝硬化患者（儿童B和C），而第2组：发生HRS的患者。Stata©14.2版软件包用于分析。
■第1组包括18名男性和26名女性，而第2组包括25名男性和19名女性（p=0.135）。在校正性别的多变量logistic回归分析中，只有尿KIM-1在两组之间显示出统计学上的显著差异，血清胆红素，血清白蛋白,INR,血清K,AST和ALT水平。
■总而言之，我们的研究与先前的研究一致，如关于肝硬化AKI患者尿NGAL升高的一致发现所示。尿KIM-1，独立于尿NGAL，可能在精确区分晚期肝硬化和HRS中起作用，值得进一步探索。
