PDF(Pubmed)
Abstract：
Outdoor workers have increased risk of developing keratinocyte cancer due to accumulated skin damage resulting from chronic and excessive exposure to UVR. This study aims to identify potential noninvasive biomarkers to assess chronic UVR exposure. We analyzed stratum corneum biomarkers collected from 2 skin locations and 2 occupational groups with contrasting solar UVR exposure: the forehead and retroauricular skin among outdoor workers and indoor workers. Using a linear mixed model adjusting for age and skin phototype, we compared biomarkers between both skin sites in indoor and outdoor workers. We measured markers of the immune response and skin barrier, including cytokines, GFs, 15-hydroxyeicosatetraenoic acid, cis- and trans-urocanic acid, and corneocyte topography, indicated by circular nano objects. Differences between the 2 skin sites were found for cis-urocanic acid, total urocanic acid, IL-1α, IL-1RA, IL-1RA/IL-1α, IL-18, 15-hydroxyeicosatetraenoic acid, CCL4, and circular nano objects. The levels of cis-urocanic acid and CCL4 also differed between indoor and outdoor workers. These findings underscore changes in both immune response and skin barrier induced by UVR. They indicate the potential utility of stratum corneum biomarkers in detecting both chronic UVR exposure in occupational setting and aiding in the development of preventive measures.
摘要：
由于长期和过度暴露于UVR导致的累积皮肤损伤，户外工人患角质形成细胞癌的风险增加。这项研究旨在确定潜在的非侵入性生物标志物来评估慢性UVR暴露。我们分析了从2个皮肤位置和2个职业组收集的角质层生物标志物，并对比了太阳能UVR暴露：户外工人和室内工人的额头和耳后皮肤。使用线性混合模型调整年龄和皮肤照型，我们比较了室内和室外工作人员皮肤部位的生物标志物.我们测量了免疫反应和皮肤屏障的标志物，包括细胞因子,GFs,15-羟基二十碳四烯酸，顺式和反式尿酸，和角质细胞地形图，由圆形纳米物体表示。2个皮肤部位之间的差异被发现为顺式尿路酸，总尿路酸，IL-1α,IL-1RA,IL-1RA/IL-1α，IL-18，15-羟基二十碳四烯酸，CCL4和圆形纳米物体。室内和室外工人的顺式尿酸和CCL4的水平也不同。这些发现强调了UVR诱导的免疫应答和皮肤屏障的变化。它们表明角质层生物标志物在检测职业环境中的慢性UVR暴露和帮助制定预防措施方面的潜在效用。
