PDF(Pubmed)
Abstract：
Pediatric acute liver failure is a rare but serious complication of Coronavirus infections. Our patient is a previously healthy 8-year-old male who presented with acute liver failure in the setting of human coronavirus HKU1 (HCoV-HKU1) infection while asymptomatic from a respiratory perspective. During the hospital course, he developed acute hepatic encephalopathy and was listed for liver transplantation, but fortunately recovered remaining status 7 (inactive) on the transplant list. With a negative diagnostic evaluation other than his viral infection and hyperdense CD8 T-cells on liver immunohistochemical staining, pediatric acute liver failure (PALF) immune dysregulation phenotype was diagnosed.
摘要：
小儿急性肝衰竭是冠状病毒感染的罕见但严重的并发症。我们的患者是先前健康的8岁男性，在人类冠状病毒HKU1（HCoV-HKU1）感染下出现急性肝衰竭，但从呼吸道角度无症状。在住院期间，他患上了急性肝性脑病，并被列入肝移植名单，但幸运的是恢复了移植名单上的剩余状态7（不活跃）。除了他的病毒感染和肝脏免疫组织化学染色高密度CD8T细胞外，诊断评估为阴性，诊断为小儿急性肝衰竭（PALF）免疫失调表型。
