%0 Case Reports
%T Coronavirus HKU1 infection and development of pediatric acute liver failure with immune dysregulation phenotype.
%A Ajmera A
%A Pernicone PJ
%A Patel N
%A Benabe SH
%J JPGN Rep
%V 5
%N 2
%D 2024 May
%M 38756108
暂无%R 10.1002/jpr3.12065
%X Pediatric acute liver failure is a rare but serious complication of Coronavirus infections. Our patient is a previously healthy 8-year-old male who presented with acute liver failure in the setting of human coronavirus HKU1 (HCoV-HKU1) infection while asymptomatic from a respiratory perspective. During the hospital course, he developed acute hepatic encephalopathy and was listed for liver transplantation, but fortunately recovered remaining status 7 (inactive) on the transplant list. With a negative diagnostic evaluation other than his viral infection and hyperdense CD8 T-cells on liver immunohistochemical staining, pediatric acute liver failure (PALF) immune dysregulation phenotype was diagnosed.