Abstract：
UNASSIGNED: Breast cancer (BC) is the leading cause of cancer death among women worldwide. The nudix hydrolase 17 (NUDT17) may play notable roles in cancer growth and metastasis. In this study, we explored the importance of NUDT17 gene polymorphism in patients with BC.
UNASSIGNED: In our study, 563 BC patients and 552 healthy controls participated. We used logistic regression analysis to calculate odds ratios (OR) and 95% confidence intervals (CI), and multifactor dimension reduction (MDR) analysis of SNP-SNP interactions. Finally, UALCAN and THPA databases were used for bioinformatics analysis.
UNASSIGNED: The rs9286836 G allele was associated with a decreased the BC risk (p = 0.022), and the carriers of rs2004659 G allele had a 32% decreased risk of BC than individuals with allele A (p = 0.004). In the four genetic models, rs9286836 and rs2004659 reduced the risk of BC. Additionally, we found that the NUDT17 SNPs were associated with BC risk under age, tumor size, and clinical stage stratification. The MDR analysis showed that the five-locus interaction model was the best in the multi-locus model.
UNASSIGNED: Our study found that NUDT17 single nucleotide polymorphisms are associated with BC susceptibility in Chinese Han population.
UNASSIGNED: In our study, 563 BC patients and 552 healthy controls participated. We used logistic regression analysis to calculate odds ratios (OR) and 95% confidence intervals (CI), and multifactor dimension reduction (MDR) analysis of SNP-SNP interactions. Finally, UALCAN and THPA databases were used for bioinformatics analysis.
UNASSIGNED: The rs9286836 G allele was associated with a decreased the BC risk (p = 0.022), and the carriers of rs2004659 G allele had a 32% decreased risk of BC than individuals with allele A (p = 0.004). In the four genetic models, rs9286836 and rs2004659 reduced the risk of BC. Additionally, we found that the NUDT17 SNPs were associated with BC risk under age, tumor size, and clinical stage stratification. The MDR analysis showed that the five-locus interaction model was the best in the multi-locus model.
UNASSIGNED: Our study found that NUDT17 single nucleotide polymorphisms are associated with BC susceptibility in Chinese Han population.
摘要：
乳腺癌（BC）是全球女性癌症死亡的主要原因。nudix水解酶17（NUDT17）可能在癌症的生长和转移中起重要作用。在这项研究中,我们探讨了NUDT17基因多态性在BC患者中的重要性。
■在我们的研究中，563例BC患者和552例健康对照者参加。我们使用逻辑回归分析来计算比值比(OR)和95%置信区间(CI)，SNP-SNP相互作用的多因子降维(MDR)分析。最后,UALCAN和THPA数据库用于生物信息学分析。
■rs9286836G等位基因与BC风险降低相关（p=0.022），rs2004659G等位基因携带者的BC风险比具有等位基因A的个体降低32%(p=0.004)。在四种遗传模型中,rs9286836和rs2004659降低了BC的风险。此外,我们发现NUDT17SNP与年龄以下的BC风险相关，肿瘤大小,和临床分期分层。MDR分析表明，在多位点模型中，五基因座相互作用模型最好。
■我们的研究发现NUDT17单核苷酸多态性与中国汉族人群的BC易感性相关。
■在我们的研究中，563例BC患者和552例健康对照者参加。我们使用逻辑回归分析来计算比值比(OR)和95%置信区间(CI)，SNP-SNP相互作用的多因子降维(MDR)分析。最后,UALCAN和THPA数据库用于生物信息学分析。
■rs9286836G等位基因与BC风险降低相关（p=0.022），rs2004659G等位基因携带者的BC风险比具有等位基因A的个体降低32%(p=0.004)。在四种遗传模型中,rs9286836和rs2004659降低了BC的风险。此外,我们发现NUDT17SNP与年龄以下的BC风险相关，肿瘤大小,和临床分期分层。MDR分析表明，在多位点模型中，五基因座相互作用模型最好。
■我们的研究发现NUDT17单核苷酸多态性与中国汉族人群的BC易感性相关。
