PDF(Pubmed)
Abstract：
BACKGROUND: Pre-eclampsia and migraine share some similar aspects of pathophysiology such as vascular function, platelet activation, and enhanced clotting. A few observational studies from different demographics showed that pregnant women with a history of migraine were at higher risk of developing pre-eclampsia. However, there is no such evidence available from the Indian context. Hence, a hospital-based case-control study was conducted among Indian women to determine the association between migraine and pre-eclampsia.
METHODS: It was a single-centre case-control study in a tertiary care hospital in India. Cases were pregnant women with clinically diagnosed pre-eclampsia, and controls were normotensive pregnant women. Migraine was diagnosed with a questionnaire adapted from the \"International Classification of Headache Disorders (ICHD), 3rd Edition\" by the International Headache Society, (IHS). We performed logistic regression to explore the association between migraine and pre-eclampsia.
RESULTS: One hundred sixty-four women (82 women per group) were enrolled. The mean age among the cases (24.5 years, standard deviation of 2.4 years) was slightly higher than the mean age of the controls (23.5 years, standard deviation of 2.5 years) with a p-value of 0.006. We found that women with a history of migraine were more likely to develop pre-eclampsia (Adjusted Odds Ratio 6.17; p-value < 0.001, 95% Confidence Interval of 2.85 to 13.62).
CONCLUSIONS: The current findings suggest a significant association between migraine and pre-eclampsia aligning with previous study findings; nevertheless, larger follow-up studies including women from different states in India are needed.
METHODS: It was a single-centre case-control study in a tertiary care hospital in India. Cases were pregnant women with clinically diagnosed pre-eclampsia, and controls were normotensive pregnant women. Migraine was diagnosed with a questionnaire adapted from the \"International Classification of Headache Disorders (ICHD), 3rd Edition\" by the International Headache Society, (IHS). We performed logistic regression to explore the association between migraine and pre-eclampsia.
RESULTS: One hundred sixty-four women (82 women per group) were enrolled. The mean age among the cases (24.5 years, standard deviation of 2.4 years) was slightly higher than the mean age of the controls (23.5 years, standard deviation of 2.5 years) with a p-value of 0.006. We found that women with a history of migraine were more likely to develop pre-eclampsia (Adjusted Odds Ratio 6.17; p-value < 0.001, 95% Confidence Interval of 2.85 to 13.62).
CONCLUSIONS: The current findings suggest a significant association between migraine and pre-eclampsia aligning with previous study findings; nevertheless, larger follow-up studies including women from different states in India are needed.
摘要：
背景：先兆子痫和偏头痛在病理生理学上有一些相似的方面，例如血管功能，血小板活化,和增强凝血。来自不同人口统计学的一些观察性研究表明，有偏头痛病史的孕妇患先兆子痫的风险更高。然而,从印度的情况来看，没有这样的证据。因此，在印度女性中进行了一项基于医院的病例对照研究,以确定偏头痛和先兆子痫之间的相关性.
方法：这是印度一家三级医院的单中心病例对照研究。病例为临床诊断为先兆子痫的孕妇，对照组为血压正常的孕妇。偏头痛被诊断为根据“国际头痛疾病分类（ICHD）”改编的问卷，第三版“由国际头痛学会，（IHS）。我们进行了逻辑回归，以探讨偏头痛和先兆子痫之间的关系。
结果：纳入了164名女性（每组82名女性）。病例的平均年龄(24.5岁，标准差为2.4岁)略高于对照组的平均年龄(23.5岁，标准偏差为2.5年)，p值为0.006。我们发现，有偏头痛病史的女性更容易发生先兆子痫（调整后的赔率比6.17；p值<0.001，95％置信区间为2.85至13.62）。
结论：目前的研究结果表明，与以前的研究结果一致，偏头痛和先兆子痫之间存在显著关联；然而，需要更大的后续研究，包括来自印度不同州的女性。
方法：这是印度一家三级医院的单中心病例对照研究。病例为临床诊断为先兆子痫的孕妇，对照组为血压正常的孕妇。偏头痛被诊断为根据“国际头痛疾病分类（ICHD）”改编的问卷，第三版“由国际头痛学会，（IHS）。我们进行了逻辑回归，以探讨偏头痛和先兆子痫之间的关系。
结果：纳入了164名女性（每组82名女性）。病例的平均年龄(24.5岁，标准差为2.4岁)略高于对照组的平均年龄(23.5岁，标准偏差为2.5年)，p值为0.006。我们发现，有偏头痛病史的女性更容易发生先兆子痫（调整后的赔率比6.17；p值<0.001，95％置信区间为2.85至13.62）。
结论：目前的研究结果表明，与以前的研究结果一致，偏头痛和先兆子痫之间存在显著关联；然而，需要更大的后续研究，包括来自印度不同州的女性。
