Abstract：
It has generally been accepted that vitamin E refers to a group of tocochromanols, α-, β-, γ-, and δ-tocopherols and the corresponding four tocotrienols. Recently, Azzi and colleagues proposed to restrict the term vitamin E only to RRR-α-tocopherol, not to other tocopherols and tocotrienols (Azzi A et al. Free Radic Biol Med. 2023; 207:178-180. doi: 10.1016/j.freeradbiomed.2023.06.029). The aim of this paper is to express our opinion on the nomenclature of vitamin E based on available scientific data. In our opinion, it would be inappropriate to exclude all the tocochromanols other than RRR-α-tocopherol from the vitamin E group at this stage when the molecular mechanisms showing how vitamin E deficiency causes diseases such as ataxia and how vitamin E prevents/reverses such diseases are not elucidated. Understanding of whole functions of tocochromanols including underlying mechanisms and dynamics is essential before revision of currently accepted definition of vitamin E. The potential roles of γ-tocopherol and tocotrienols are discussed despite whether they are vitamin function should be clarified in the future studies.
摘要：
人们普遍认为，维生素E是指一组生育色酚，α-,β-,γ-,和δ-生育酚和相应的四种生育三烯酚。最近,Azzi及其同事建议将术语维生素E仅限于RRR-α-生育酚，不适用于其他生育酚和生育三烯酚(AzziA，etal.免费RadicBiolMed.2023年；207：178-180。doi：10.1016/j.免费生物2023.06.029）。本文的目的是根据现有的科学数据表达我们对维生素E命名的看法。在我们看来,在此阶段,当显示维生素E缺乏如何引起诸如共济失调等疾病以及维生素E如何预防/逆转此类疾病的分子机制尚未阐明时,将除RRR-α-生育酚以外的所有生育色醇从维生素E组中排除是不合适的。在修订目前公认的维生素E定义之前，了解生育色酚的整体功能，包括潜在的机制和动力学是必不可少的。讨论了γ-生育酚和生育三烯酚的潜在作用，尽管它们是否是维生素功能，应在未来的研究中阐明。
