scRank 使用目标扰动的基因调控网络从未处理的 scRNA - seq 数据中推断药物反应性细胞类型。
关键词: cell-type prioritization drug response gene network perturbation single cell
Mesh : Gene Regulatory Networks / drug effects Humans Single-Cell Analysis / methods Medulloblastoma / genetics drug therapy pathology RNA-Seq / methods Animals Depressive Disorder, Major / genetics drug therapy Transcriptome / genetics drug effects Gene Expression Profiling / methods Macrophages / metabolism drug effects Myocardial Infarction / genetics drug therapy Single-Cell Gene Expression Analysis
来 源:
DOI:10.1016/j.xcrm.2024.101568
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