Abstract：
BACKGROUND: Higher mean and rapid increases in body mass index (BMI) during infancy are associated with subsequent obesity and may be influenced by exposure to endocrine-disrupting chemicals such as phenols.
OBJECTIVE: In a prospective US-based cohort conducted 2010-2014, we investigated associations between environmental phenol exposures and BMI in 199 infants.
METHODS: We measured seven urinary phenols at ages 6-8 and 12 weeks and assessed BMI z-score at up to 12 study visits between birth and 36 weeks. We examined individual and joint associations of averaged early infancy phenols with level of BMI z-score using mean differences (β [95% confidence intervals (CI)]) and with BMI z-score trajectories using relative risk ratios (RR [95% CI]).
RESULTS: Benzophenone-3, methyl and propyl paraben, and all phenols jointly were positively associated with higher mean BMI z-score (0.07 [-0.05, 0.18], 0.10 [-0.08, 0.27], 0.08 [-0.09, 0.25], 0.17 [-0.08, 0.43], respectively). Relative to a Stable trajectory, benzophenone-3, 2,4-dichlorophenol, 2,5-dichlorophenol, and all phenols jointly were positively associated with risk of a Rapid Increase trajectory (1.46 [0.89, 2.39], 1.33 [0.88, 2.01], 1.66 [1.03, 2.68], 1.41 [0.71, 2.84], respectively).
CONCLUSIONS: Early phenol exposure was associated with a higher mean and rapid increase in BMI z-score across infancy, signaling potential long-term cardiometabolic consequences of exposure.
OBJECTIVE: In a prospective US-based cohort conducted 2010-2014, we investigated associations between environmental phenol exposures and BMI in 199 infants.
METHODS: We measured seven urinary phenols at ages 6-8 and 12 weeks and assessed BMI z-score at up to 12 study visits between birth and 36 weeks. We examined individual and joint associations of averaged early infancy phenols with level of BMI z-score using mean differences (β [95% confidence intervals (CI)]) and with BMI z-score trajectories using relative risk ratios (RR [95% CI]).
RESULTS: Benzophenone-3, methyl and propyl paraben, and all phenols jointly were positively associated with higher mean BMI z-score (0.07 [-0.05, 0.18], 0.10 [-0.08, 0.27], 0.08 [-0.09, 0.25], 0.17 [-0.08, 0.43], respectively). Relative to a Stable trajectory, benzophenone-3, 2,4-dichlorophenol, 2,5-dichlorophenol, and all phenols jointly were positively associated with risk of a Rapid Increase trajectory (1.46 [0.89, 2.39], 1.33 [0.88, 2.01], 1.66 [1.03, 2.68], 1.41 [0.71, 2.84], respectively).
CONCLUSIONS: Early phenol exposure was associated with a higher mean and rapid increase in BMI z-score across infancy, signaling potential long-term cardiometabolic consequences of exposure.
摘要：
背景：婴儿期体重指数（BMI）较高的平均值和快速增加与随后的肥胖有关，并且可能受到暴露于内分泌干扰化学物质如酚的影响。
目的：在2010-2014年进行的前瞻性美国队列中，我们调查了199名婴儿环境苯酚暴露与BMI之间的关系。
方法：我们在6-8岁和12周时测量了7种尿酚，并在出生至36周时的12次研究访视时评估了BMIz评分。我们使用平均差异（β[95％置信区间（CI）]）和使用相对风险比（RR[95％CI]）与BMIz评分轨迹检查了平均早期婴儿期酚类物质与BMIz评分水平的个体和联合关联。
结果：二苯甲酮-3，对羟基苯甲酸甲酯和对羟基苯甲酸丙酯，和所有酚类共同与较高的平均BMIz评分呈正相关(0.07[-0.05，0.18]，0.10[-0.08,0.27],0.08[-0.09,0.25],0.17[-0.08,0.43],分别)。相对于稳定轨迹，二苯甲酮-3,2,4-二氯苯酚,2,5-二氯苯酚,和所有酚类共同与快速增加轨迹的风险呈正相关(1.46[0.89，2.39]，1.33[0.88,2.01],1.66[1.03,2.68],1.41[0.71,2.84],分别)。
结论：早期苯酚暴露与婴儿期BMIz评分的平均值较高且快速增加有关，信号潜在的长期心脏代谢暴露的后果。
目的：在2010-2014年进行的前瞻性美国队列中，我们调查了199名婴儿环境苯酚暴露与BMI之间的关系。
方法：我们在6-8岁和12周时测量了7种尿酚，并在出生至36周时的12次研究访视时评估了BMIz评分。我们使用平均差异（β[95％置信区间（CI）]）和使用相对风险比（RR[95％CI]）与BMIz评分轨迹检查了平均早期婴儿期酚类物质与BMIz评分水平的个体和联合关联。
结果：二苯甲酮-3，对羟基苯甲酸甲酯和对羟基苯甲酸丙酯，和所有酚类共同与较高的平均BMIz评分呈正相关(0.07[-0.05，0.18]，0.10[-0.08,0.27],0.08[-0.09,0.25],0.17[-0.08,0.43],分别)。相对于稳定轨迹，二苯甲酮-3,2,4-二氯苯酚,2,5-二氯苯酚,和所有酚类共同与快速增加轨迹的风险呈正相关(1.46[0.89，2.39]，1.33[0.88,2.01],1.66[1.03,2.68],1.41[0.71,2.84],分别)。
结论：早期苯酚暴露与婴儿期BMIz评分的平均值较高且快速增加有关，信号潜在的长期心脏代谢暴露的后果。
