Abstract：
Compared with full-term infants, preterm infants have fat-free mass deficit in the first months of life, which increases the risk of metabolic diseases in the future. In this cohort of children born under 32-week gestational age or less than 1500 g, we aimed to evaluate the associations of body composition at term equivalent age and in the first 3 months of life with fat-free mass and fat mass percentage at 4 to 7 years of life. Body composition assessments by air displacement plethysmography and anthropometry were performed at term, at 3 months of corrected age, and at 4 to 7 years of age. Multiple linear regression analysis was used to observe the associations between body composition at these ages. At term, fat mass percentage showed a negative association and fat-free mass a positive association with fat-free mass at 4 to 7 years. The fat-free mass at 3 months and the gain in fat-free mass between term and 3 months showed positive associations with fat-free mass at 4 to 7 years. Conclusion: Body composition at preschool age is associated with fat-free mass in the first 3 months of life, a sensitive period for the risk of metabolic diseases. What is Known: • Preterm infants have a deficit in fat-free mass and high adiposity at term equivalent age compared to full-term infants. • Fat-free mass reflects metabolic capacity throughout life and therefore is considered a protective factor against the risk of metabolic syndrome. What is New: •Fat-free mass gain in the first 3 months of corrected age is associated with fat-free mass at preschool and school ages. •The first 3 months of life is a sensitive period to the risk of metabolic diseases.
摘要：
与足月婴儿相比，早产儿在出生后的头几个月有无脂质量赤字，这增加了未来代谢性疾病的风险。在这个出生在32周胎龄以下或小于1500克的儿童队列中，我们的目的是评估足月等效年龄时和出生后前3个月时的身体成分与4~7岁时的无脂肪量和脂肪量百分比之间的关系.在足月进行了通过空气置换体积描记术和人体测量术进行的身体成分评估，在矫正年龄3个月时，4至7岁。使用多元线性回归分析来观察这些年龄的身体成分之间的关联。在学期，4~7年时,脂肪质量百分比呈负相关,无脂肪质量与无脂肪质量呈正相关.3个月时的无脂质量和足月至3个月之间的无脂质量增加与4至7年的无脂质量呈正相关。结论：学龄前的身体成分与生命最初3个月的无脂肪量有关，代谢疾病风险的敏感期。已知:•与足月婴儿相比,早产儿在足月等效年龄时具有无脂肪质量的不足和高肥胖。•无脂质量反映了整个生命的代谢能力，因此被认为是预防代谢综合征风险的保护因素。新增内容:•校正年龄的前3个月的无脂质量增加与学龄前和学龄期的无脂质量有关。•生命的前3个月是代谢疾病风险的敏感期。
